Broiler chickens exposed to melamine and cyanuric acid-contaminated diets

Human & Experimental Toxicology
D ZapletalP Suchý

Abstract

The objective of this study was to investigate whether melamine (MEL) is biotransformed into cyanuric acid (CYA) in male broiler chickens. The effects of the dietary addition of MEL and CYA alone and in combination on the growth performance and mortality of the chickens were also investigated. The chickens were divided into six experimental groups and were fed diets with an addition of 50 or 100 mg/kg MEL or 50 or 100 mg/kg CYA of diet, with the contaminants added separately or in combination. The control group was fed a diet without MEL or CYA. At the end of the experiment (day 40), samples of liver, kidney and breast and thigh muscles were collected from 12 birds per treatment group and were analysed for the presence of MEL and CYA. This study showed that MEL is biotransformed into CYA in broilers. Higher concentrations of MEL or CYA in the diet increased the presence of their residues in tissues, and the CYA residue concentration was several times higher in the respective tissues than the MEL residue concentration. The dietary addition of MEL and CYA did not affect the mortality rate, feed conversion ratio or body weight of the chickens.

References

Mar 17, 2010·Journal of Agricultural and Food Chemistry·Chun-Qi GaoGuang-Hai Qi
Apr 16, 2010·Journal of Agricultural and Food Chemistry·Xue BaiShunquan Lin
Aug 3, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R ReimschuesselC M Gieseker
Aug 24, 2010·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·X F DongQ Zhang
May 21, 2011·Poultry Science·C ValatG Postollec
Oct 27, 2011·Human & Experimental Toxicology·X-M DingS-P Bai
Feb 7, 2012·Toxicology and Applied Pharmacology·Jean Lou DorneDiane Benford
Jul 18, 2012·Poultry Science·L M BrandG E Rottinghaus
Feb 15, 2013·Science Translational Medicine·Xiaojiao ZhengWei Jia

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Citations

Jan 10, 2018·Environmental Toxicology and Chemistry·David B Mayfield, Daniel G Skall

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