Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium

American Journal of Physiology. Heart and Circulatory Physiology
Bela JuhaszNilanjana Maulik

Abstract

Bromelain (Br), a proteolytic enzyme extracted from the stem of the pineapple, is known to possess anti-inflammatory activity and has been shown to reduce blood viscosity, prevent the aggregation of blood platelets, and improve ischemia-reperfusion (I/R) injury in a skeletal muscle model. We investigated the capacity of Br to limit myocardial injury in a global I/R model. Adult male Sprague-Dawley rats were divided into two groups: control (PBS) and Br at 10 mg/kg in PBS administered via intraperitoneal injection (twice/day) for 15 consecutive days. On day 16, the hearts were excised and subjected to 30 min of global ischemia followed by 2 h of reperfusion. Br treatment showed higher left ventricular functional recovery throughout reperfusion compared with the controls [maximum rate of rise in intraventricular pressure (dP/dt max), 2,225 vs. 1,578 mmHg/s at 2 h reperfusion]. Aortic flow was also found to be increased in Br treatment when compared with that in untreated rats (11 vs. 1 ml). Furthermore, Br treatment reduced both the infarct size (34% vs. 43%) and the degree of apoptosis (28% vs. 37%) compared with the control animals. Western blot analysis showed an increased phosphorylation of both Akt and FOXO3A in the treatmen...Continue Reading

References

Jan 8, 1999·Basic Research in Cardiology·P AnversaJ Kajstura
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Oct 2, 2001·Cellular and Molecular Life Sciences : CMLS·H R Maurer
Nov 10, 2001·Trends in Biochemical Sciences·D P Brazil, B A Hemmings
Feb 28, 2004·Circulation Research·Isao ShiraishiMark A Sussman
Mar 10, 2004·The Biochemical Journal·Lars P Van Der HeideMarten P Smidt
Apr 17, 2004·Circulation Research·Keith A Webster
Feb 7, 2006·The Journal of Surgical Research·Christoph NeumayerIhor Huk
Jul 15, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Mahesh ThirunavukkarasuNilanjana Maulik
Nov 30, 2006·The Journal of Pharmacology and Experimental Therapeutics·Suresh Varma PenumathsaNilanjana Maulik
Dec 26, 2006·Journal of Molecular and Cellular Cardiology·Suresh Varma PenumathsaNilanjana Maulik

❮ Previous
Next ❯

Citations

Aug 21, 2013·Experimental and Molecular Pathology·Xu-Feng QiDong-Qing Cai
Jul 12, 2011·Physiological Reviews·Mark A SussmanMichael McGregor
Jul 14, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Chit Moy LeyNicola Robinson
Nov 1, 2015·Biotechnology Progress·Letícia Celia de Lencastre NovaesAdalberto Pessoa Junior
Jan 11, 2013·Biotechnology Research International·Rajendra PavanAjay Kumar
Oct 13, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miklos SzokolBela Juhasz
Jan 1, 2019·The International Journal of Neuroscience·Hongzhi ZhouXia Chen
May 28, 2019·FEBS Letters·Ji-Yang SongMan-Wook Hur
Jun 9, 2020·Therapeutic Delivery·Sally A HelmySoha M El-Masry
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Csaba HegedűsRita Kiss
Apr 16, 2016·International Journal of Molecular Medicine·Mi-Hua LiuZhi-Sheng Jiang
Sep 8, 2016·Biomedical Reports·Vidhya RathnaveluRajendran Ramesh
Mar 22, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Jing LiTerry L Vanden Hoek
Nov 26, 2020·International Journal of Molecular Sciences·Renáta SzabóAnikó Pósa
Nov 5, 2020·Burns : Journal of the International Society for Burn Injuries·Daniel A HofmaennerJan A Plock
Nov 27, 2021·Integrative Cancer Therapies·Mai H MekkawyOla S Ali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.