PMID: 591982Dec 1, 1977

Bromocriptine alone or associated with L-dopa plus benserazide in Parkinson's disease

Journal of Neurology, Neurosurgery, and Psychiatry
T CaraceniF Girotti

Abstract

Twenty-six patients affected by Parkinson's disease were treated with a 2-Br-alpha-ergocriptine (CB 154): 14 cases were given CB 154 alone, and 12 were given CB 154 along with L-dopa plus benserazide (Madopar). Both CB 154 and combined therapy (CB 154+Madopar) induced a significant improvement in total disability score, tremor, rigidity, akinesia, self-sufficiency, and some motor performance tests (dynamic tests). No significant difference was found between results obtained with CB 154 therapy and with Madopar treatment, while the improvement induced by combined therapy (CB 154+Madopar) was significantly higher than that obtained by Madopar alone. The averse reactions caused by CB 154 alone or associated with Madopar are similar to those observed during other dopaminergic treatment. CB 154 alone or combined with Madopar appears to be a useful advance in the management of Parkinson's disease.

References

May 1, 1975·Neurology·A N LiebermanM Goldstein
Feb 1, 1976·Journal of Neurology, Neurosurgery, and Psychiatry·J D ParkesP Asselman
May 1, 1976·Neurology·A N LiebermanM Goldstein
Jun 1, 1976·Neurology·R Kartznel, D B Calne
Dec 16, 1976·The New England Journal of Medicine·A N LiebermanM Goldstein
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Citations

Apr 1, 1983·Italian Journal of Neurological Sciences·P GiovanniniT Caraceni
Apr 1, 1982·Australian and New Zealand Journal of Medicine·J G Morris
Jun 1, 1981·Journal of the American Geriatrics Society·M M Hoehn
Feb 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J D Grimes
Aug 1, 1987·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·S Bouchard

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