PMID: 9181047Jan 1, 1997Paper

Bromocriptine has little direct effect on murine lymphocytes, the immunomodulatory effect being mediated by the suppression of prolactin secretion

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
M Neidhart

Abstract

We investigated whether the immunosuppressive effect of bromocriptine in mice is due to its direct effect on lymphocyte functions or through inhibition of prolactin secretion. Incubation of mouse Babl/c splenic lymphocytes with bromocriptine in vitro at a concentration of around 0.5 to 1 microgram/mL causes an inhibition of antigen- or mitogen-induced proliferation. However, bromocriptine in vitro has no effect on lymphokine production (gamma-interferon and interleukin-2), expression of interleukin-2 receptor or lymphocyte cytotoxic function. Furthermore, treatment of Babl/c mice with bromocriptine inhibits the mixed lymphocyte reaction and mitogen stimulation, as well as primary and secondary antibody production. However, we postulated that the inhibition of ex vivo functional activity could not account for a direct cytostatic or cytotoxic effect of bromocriptine. This is supported by the in vitro data, which shows that bromocriptine has no effect on proliferating P-815 mastocytoma tumor cells. Finally, (NZB/NZW) F1 mice spontaneously develop a disease similar to systemic lupus erythematosus. In both non-autoimmune Babl/c mice and (NZB/NZW) F1 lupus-mice, the serum level of bromocriptine achieved by a treatment with 5 mg/kg on...Continue Reading

References

Apr 1, 1992·The American Journal of the Medical Sciences·L J JaraL R Espinoza
Aug 1, 1991·Endocrinology·S M ViselliA M Mastro
Jan 1, 1987·Immunopharmacology and Immunotoxicology·E KouassiJ P Revillard
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T S KupperM C Horowitz
Nov 1, 1980·Journal of Pharmacobio-dynamics·A IchikawaK Tomita
Jan 1, 1982·Cancer Chemotherapy and Pharmacology·B F IssellM E Curry
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·G O Gaufo, M C Diamond

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Citations

Oct 24, 1998·Domestic Animal Endocrinology·S L Davis
Jul 29, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M NeidhartS Gay
Jun 16, 2001·International Immunopharmacology·R W McMurray
Dec 6, 2000·The Journal of Clinical Investigation·E PeevaB Diamond
Jan 18, 2003·The Journal of Clinical Investigation·Elena PeevaBetty Diamond
Aug 3, 2005·Immunology Letters·Elena Peeva, Moncef Zouali
Nov 28, 2001·Lupus·L J JaraJ Alvarez-Nemegyei
Nov 28, 2001·Lupus·R W McMurray
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
May 17, 2003·International Journal of Immunopathology and Pharmacology·J JurcovicovaR Rokyta

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