PMID: 6403950Feb 1, 1983Paper

Bromocriptine promotes recovery of self-stimulation in 6-hydroxydopamine-lesioned rats

Pharmacology, Biochemistry, and Behavior
R J Carey

Abstract

Rats with stable self-stimulation response rate-current intensity functions were subjected to bilateral 6-hydroxydopamine injections into the substantia nigra. The effect of several drug treatments were evaluated on the 6-hydroxydopamine lesion self-stimulation deficit. d-Amphetamine (1.0, 2.0 and 3.0 mg/kg) and scopolamine (0.25, 0.5 and 1.0 mg/kg) had little or no effect on self-stimulation, but bromocriptine (2.0 and 4.0 mg/kg) produced a nearly complete recovery of self-stimulation performance. In contrast, scopolamine increased locomotor activity: whereas, bromocriptine did not increase activity. These results point up the efficacy of bromocriptine in reversing self-stimulation deficits induced by a dopamine deficiency, and indicate that self-stimulation may be a more useful behavior than locomotor activity for evaluating drugs which might alleviate Parkinsonism.

Citations

Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·C M Knapp, C Kornetsky
May 14, 1998·Neuroscience and Biobehavioral Reviews·R J Beninger, R Miller
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·G L Willis

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