PMID: 8447396Feb 1, 1993Paper

Bromocriptine redirects metabolism and prevents seasonal onset of obese hyperinsulinemic state in Syrian hamsters

The American Journal of Physiology
A H CincottaA H Meier

Abstract

Bromocriptine redirects metabolism and prevents seasonal onset of the obese hyperinsulinemic state in Syrian hamsters. Metabolic and hormonal effects of bromocriptine were studied in seasonally obese female Syrian hamsters, Mesocricetus auratus. Daily injections of bromocriptine and vehicle (controls) were made at light onset (10:14-h light-dark cycle) for 10 wk. After 9 wk of treatment blood samples were taken every 4 h during a day for assays of hormones, glucose, triglyceride, and fatty acids, and after 10 wk of treatment, tests were carried out to measure insulin-stimulated glucose disposal during a hyperinsulinemic clamp, lipid mobilization (rate of glycerol appearance), protein turnover (lysine flux and deamination), and body composition (deuterium dilution). Bromocriptine reduced percent body fat by 53% and increased percent lean body mass by 8%. It also decreased triglyceride levels by 52% and plasma free fatty acid concentration during the dark-near light onset by 49% and glycerol appearance by 25%. Protein synthesis and catabolism were increased by 62 and 56%, respectively, and deamination of amino acid was decreased by 53% by bromocriptine. Bromocriptine reduced plasma concentration of insulin throughout the day, esp...Continue Reading

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Citations

Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R V WeberJ G Kral
Dec 4, 2019·American Journal of Physiology. Endocrinology and Metabolism·Sarah N Framnes-DeBoerDeanna M Arble
Jun 29, 2006·American Journal of Physiology. Endocrinology and Metabolism·Petra KokHanno Pijl
Jun 14, 2019·Frontiers in Endocrinology·Renata S AuriemmaAnnamaria Colao
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A H CincottaP W Scislowski
Jul 31, 2018·Expert Review of Endocrinology & Metabolism·Renata S AuriemmaAnnamaria Colao
May 28, 2020·American Journal of Physiology. Endocrinology and Metabolism·Mary Courtney MooreAlan D Cherrington

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