Bromodeoxyuridine-induced expression of endothelin A in A375 human melanoma cells

Biochemical and Biophysical Research Communications
T OhtaniT Masaki

Abstract

Expression of endothelin (ET) receptor subtypes was examined in an experimental model of A375 human melanoma cell differentiation using the pyrimidine analog bromodeoxyuridine (BUdR). BUdR (10 microM)-treated cells had an increased surface area and an increased dendricity, were contact-inhibited and lacked tumorigenecity in athymic nude mice. The untreated A375 cells exclusively expressed ETB and BUdR-induced phenotypical changes were accompanied by induction of ETA expression as evidenced by northern blotting, [125I]ET-1 binding assay and [Ca2+]i measurement. Thus, BUdR-induced differentiation of A375 melanoma cells may provide a model system to study the receptor subtype switch in melanocyte development.

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Citations

Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·R LahavP H Patterson
Jun 20, 1998·The Journal of Biological Chemistry·M OkazawaT Masaki
Mar 19, 2003·Differentiation; Research in Biological Diversity·Derek WalshMartin Clynes

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