Bromodomain protein BRD4 is increased in human placentas from women with early-onset preeclampsia

Reproduction : the Official Journal of the Society for the Study of Fertility
Stella LiongMartha Lappas

Abstract

Preeclampsia affects 5% of all pregnancies and is a serious disorder of pregnancy, characterised by high maternal blood pressure, placental hypoxia, fluid retention (oedema) and proteinuria. Women with preeclampsia are associated with exaggerated levels of pro-inflammatory cytokines, chemokines and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFLT1). Studies in non-gestational tissues have described the bromodomain (BRD) and extraterminal family of proteins, in particular BRD4 to play a critical role in propagating inflammation and is currently a therapeutic target for treating cancer, lung inflammation and asthma. The aims of this study were to: (i) determine the effect of severe early-onset preeclampsia on placental BRD4 expression; (ii) the effect of loss of BRD4 function by siRNA-targeted knockdown or with the BRD inhibitor JQ1 in human primary trophoblast cells and human umbilical vein endothelial cells (HUVECs) on TNF-stimulated production of pro-inflammatory mediators, cell adhesion molecules and anti-angiogenic markers and (iii) the effect of BRD4 suppression on placental sFLT1 secretion under hypoxia conditions and in preeclampic placenta. BRD4 mRNA expression was significantly increased (sevenfo...Continue Reading

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Oct 23, 2017·Journal of Reproductive Immunology·Bei XuAngela Makris

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Citations

Nov 22, 2019·Clinical Science·Ratana LimMartha Lappas
Mar 29, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·John T SzilagyiRebecca C Fry
Jan 20, 2021·Signal Transduction and Targeted Therapy·Nian WangRui Kang
Nov 2, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Mustafa BehramYasemin Doğan

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