PMID: 6973085Nov 1, 1980Paper

Bromouracil-induced mutagenesis in a mismatch-repair-deficient strain of Haemophilus influenzae

Mutation Research
H Bagci, J H Stuy

Abstract

Cells of wild-type Haemophilus influenzae and of a mismatch-repair-deficient mutant (hex-) were grown in a chemically defined medium containing either thymidine or 5-bromodeoxyuridine (BUdR). Spontaneous mutation frequencies to resistance against 3 antibiotics observed for the thymidine cultures were 10-30 times higher for the hex- mutant. The mutation frequencies observed for the BUdR hex- culture were increased by another 10 times while those for the wild-type suspension did not differ from the frequencies seen in the thymidine medium.

References

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