PMID: 9163643May 1, 1997Paper

Bronchial and skin reactivity in asthmatic patients with and without atopic dermatitis

The European Respiratory Journal
L BrinkmanJ W Lammers

Abstract

It is unclear whether the presence and severity of atopic dermatitis (AD) is predictive for the occurrence and severity of early and late asthmatic responses to inhaled allergens. The aim of this study was to compare the bronchial effects of allergen inhalation challenge in allergic asthma (AA) and atopic dermatitis. We therefore studied these responses in: nine patients with mild-to-moderate AA without AD; eight patients with mild-to-moderate AA and mild AD; eight patients with severe AD and mild AA; and eight patients with severe AD without AA. Allergen challenge was performed by inhaling doubling doses until the dose provoking a 20% fall in forced expiratory volume in one second (PC20) was reached. The late asthmatic reaction (LAR) was defined as a fall of >20% in peak expiratory flow (PEF) between 3 and 8 h after the challenge. All but four of the patients with severe AD without AA developed an early asthmatic response (EAR). A LAR was seen in all patients with severe AD and mild AA, in four patients with mild AD and mild-to-moderate AA, and in three patients with mild-to-moderate AA without AD. The LAR was most pronounced in patients with a combination of mild AA and severe AD. This could be explained, in part, by a decrea...Continue Reading

Citations

Jan 11, 2000·Critical Care Medicine·D L Bowton
Feb 6, 2004·Pediatric Emergency Care·Russ Horowitz, Sally Reynolds
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W J LieJ S Van Der Zee
Dec 13, 2007·The Journal of Allergy and Clinical Immunology·Leif Bjermer
Apr 16, 2003·The British Journal of Dermatology·C EllisUNKNOWN ICCAD II Faculty
Jan 26, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H KyllönenS Reitamo
Aug 2, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Nikolaos G PapadopoulosAntonio Nieto
Dec 20, 2011·The British Journal of Dermatology·D G PeroniG L Piacentini
Oct 19, 2005·Life Sciences·Masafumi ShibamoriHironobu Ishiyama
Jun 22, 2005·Journal of the American Academy of Dermatology·William Abramovits
Jul 15, 2003·Journal of Biomolecular Screening·Usha WarriorDavid J Burns

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