PMID: 11929614Apr 4, 2002Paper

"Bronchial artery delivery of viral vectors for gene delivery in cystic fibrosis; superior to airway delivery?"

BMC Pulmonary Medicine
Ameet BakhaiCharles C Coutelle

Abstract

Attempts at gene therapy for the pulmonary manifestations of Cystic Fibrosis have relied mainly on airway delivery. However the efficiency of gene transfer and expression in the airway epithelia has not reached therapeutic levels. Access to epithelial cells is not homogenous for a number of reasons and the submucosal glands cannot be reached via the airways. We propose to inject gene delivery vectors directly into bronchial arteries combined with pre-delivery of vascular endothelial growth factor to increase vascular endothelial permeability and post-delivery flow reduction by balloon occlusion. Thus it may be possible to reach mucous secreting cells of the bronchial luminal epithelium and the submucosal glands in an increased and homogenous fashion. This combination of techniques to the best of our knowledge has not previously been investigated, and may enable us to overcome some of the current limitations to gene therapy for Cystic Fibrosis.

References

Dec 1, 1979·The Journal of Pediatrics·K E FellowsH Shwachman
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Jun 1, 1994·Journal of Applied Physiology·P LemarchandR G Crystal
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Jun 25, 1998·American Journal of Respiratory Cell and Molecular Biology·D DuanJ F Engelhardt
Oct 3, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·B Bigger, C Coutelle
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·G MAJNO, G E PALADE

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