PMID: 3993868Feb 1, 1985

Bronchial challenge with serotonin in asthmatics

Allergy
P Tønnesen

Abstract

Bronchial challenge with serotonin creatinine in phosphate buffer was performed in 20 stable asthmatics. In contrast to some earlier studies we observed no changes in FEV1 or FVC 0 and 2 min after provocation with increasing concentrations of serotonin (maximal concentration 20 mg/ml). In the first eight patients the PC20 histamine was 0.125-0.65 mg/ml, performed on a separate day. In three other asthmatics serotonin chloride 20 mg/ml did not affect lung function or produce any subjective symptoms. Serotonin can not be used to evaluate non-specific bronchial hyperreactivity in asthmatics.

References

Jan 1, 1988·European Journal of Clinical Pharmacology·D J StottS G Ball
Jan 1, 1995·Allergy·M CazzolaF Rossi
Dec 15, 2015·Respiratory Physiology & Neurobiology·G Córdoba-RodríguezP Segura-Medina
Oct 1, 1986·British Journal of Clinical Pharmacology·M J CushleyS T Holgate
Jul 1, 1985·Allergy·P Tønnesen, N Mygind
Jun 28, 2011·Journal of Applied Physiology·S SeehaseC Martin
Dec 20, 2019·Physiological Research·P Campos-BedollaJ L Arreola-Ramírez
Jun 27, 2001·Acta Oto-laryngologica·R UddmanL Edvinsson

Citations

May 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Feb 1, 1982·Thorax·D W Cockcroft, B A Berscheid
Jun 28, 1955·The Journal of Physiology·H HERXHEIMER

Related Concepts

Bronchial Provocation Tests
Asthma
Lobar Bronchus Structure
Bronchial Hyperreactivity
Hydroxytryptamine
Respiratory Function Tests

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