Bronchial changes in airborne tularemia

The Journal of Laryngology and Otology
H SyrjäläA Salminen

Abstract

We describe seven typhoidal tularemia patients without ulcers or lymphadenopathy, who underwent diagnostic bronchoscopy. Four patients had had obvious airborne exposure to F. tularensis during farming activities, and the remaining three had respiratory symptoms also. Bronchoscopical findings were pathological in all cases, varying from local to diffuse haemorrhagic inflammation; in one case a granulomatous tumour was seen. Early histopathological changes in three biopsies consisted of haemorrhagic oedema progressing to a non-specific inflammatory reaction, which could still be found 45 days after the onset of symptoms. Granulomatous inflammation, indistinguishable from tuberculosis or sarcoidosis, was seen in four biopsies from two patients, three to seven months after the onset. Most patients had radiographic hilar enlargement. We conclude that transmission of typhoid tularemia usually occurs through inhalation leading to bronchial changes, which correspond skin ulcerations in ulcero-glandular tularemia, the hilar enlargement corresponding to the lymph node component. We emphasize that usage of the term 'typhoidal' tularemia should be discontinued. Instead, tularemia transmitted through inhalation should be called pulmonary or...Continue Reading

References

Jun 1, 1977·Journal of Clinical Microbiology·B PittmanW B Cherry
Oct 11, 1979·The New England Journal of Medicine·S M TeutschA F Kaufmann
Jan 1, 1985·Scandinavian Journal of Infectious Diseases·C Watanakunakorn
Jul 1, 1985·Journal of Biosocial Science·G W Jones
Jan 1, 1985·Scandinavian Journal of Infectious Diseases·H SyrjäläA Salminen
Jan 1, 1971·Scandinavian Journal of Infectious Diseases·S DahlstrandB Zetterberg

❮ Previous
Next ❯

Citations

Mar 1, 1996·FEMS Immunology and Medical Microbiology·S J Stewart
May 14, 2003·Wiener klinische Wochenschrift·Arschang ValipourOtto Chris Burghuber
Apr 2, 2009·International Journal of Experimental Pathology·Michelle NelsonAndrew J H Simpson
Jul 3, 2020·ERJ Open Research·Astrid KravdalAnnette Kristiansen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Related Papers

Respiratory Care
Moncef Belhassen-GarciaJavier Pardo-Lledias
Seminars in Respiratory Infections
V Gill, B A Cunha
European Review for Medical and Pharmacological Sciences
R Hu
© 2021 Meta ULC. All rights reserved