Bronchial mucus transport velocity in patients receiving propofol and remifentanil versus sevoflurane and remifentanil anesthesia

Anesthesia and Analgesia
Thomas LedowskiStephan A Schug

Abstract

Volatile anesthetics reduce ciliary beat frequency in vitro. It has been reported that impaired bronchial mucus transport velocity (BTV) is associated with significantly increased pulmonary complications. In this study, we sought to determine in vivo differences in BTV, comparing patients having total IV anesthesia (TIVA) with propofol and remifentanil to anesthesia with sevoflurane and remifentanil. Twenty-two patients scheduled for elective general surgery were randomized to one of two groups: TIVA (propofol/remifentanil) or SEVO (sevoflurane/remifentanil). Thirty minutes after tracheal intubation, BTV was assessed by fiberoptic observation of the movement of methylene blue dye applied to the dorsal surface of the right main bronchus. BTV was significantly reduced in the SEVO group compared with the TIVA group (mean, 1.5 +/- 0.7 [0-2.3] versus 4.8 +/- 2.1 [2.3-8.8] mm/min; P < 0.0001). Anesthesia with sevoflurane may lead to significantly impaired bronchociliary clearance in comparison to TIVA. This could have implications for perioperative pulmonary complications, in particular in patients at risk for pulmonary complications.

References

Sep 1, 1972·Anesthesiology·J ChalonJ Malebranche
Apr 1, 1973·Journal of Applied Physiology·M A SacknerA Wanner
Aug 15, 1968·The New England Journal of Medicine·G A LaurenziJ J Guarneri
Sep 1, 1993·Journal of Clinical Anesthesia·F X KonradM Georgieff
Jan 1, 1994·Chest·F KonradM Georgieff
Feb 1, 1996·British Journal of Anaesthesia·D A SelwynJ A Langton
Dec 6, 1997·British Journal of Anaesthesia·J H Raphael, M W Butt

❮ Previous
Next ❯

Citations

Oct 31, 2006·Journal of Anesthesia·Hikaru NiwaMaki Mizogami
Feb 5, 2014·Anesthesiology Clinics·Katrin CampbellStephen Stayer
Jan 26, 2016·Acta Anaesthesiologica Scandinavica·M DesmetW De Corte
Sep 5, 2007·Paediatric Anaesthesia·Nigel BarkerJ Mark Ansermino
Feb 27, 2015·Frontiers in Pediatrics·Nils WelcheringCecilia W Lo
Sep 4, 2014·The Journal of International Medical Research·Hyungseok SeoJai-Hyun Hwang
Feb 8, 2014·Journal of Burn Care & Research : Official Publication of the American Burn Association·Robert A CoxHal K Hawkins
May 5, 2007·Current Opinion in Anaesthesiology·George H Meakin
Jan 16, 2008·Current Opinion in Anaesthesiology·Ron V Purugganan
May 16, 2018·Korean journal of anesthesiology·So Ron ChoiSang Yoong Park
Dec 31, 2019·Paediatric Anaesthesia·Gillian R LauderThomas Engelhardt
Sep 10, 2019·Anesthesiology and Pain Medicine·Amany Faheem OmaraMaha Lotfy Elshiekh
Aug 1, 2009·Korean journal of anesthesiology·Jae Young KimByung Woo Min
Mar 3, 2021·Scientific Reports·Kyle S FeldmanMaliha Zahid
May 11, 2021·Frontiers in Cardiovascular Medicine·Phillip S AdamsCecilia W Lo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.