Bronchial muscle peristaltic activity in the fetal rat

Pediatric Research
Omar ParvezJaques Belik

Abstract

Aside for the potential for tonic contraction, the airway smooth muscle exhibits intermittent phasic rhythmic activity that may contribute to lung growth during fetal life. Therefore, we examined 4th generation rat 18-22 d gestation fetal, 4-6 d of age newborn and adult bronchial ring from Sprague Dawley rats to compare differences in smooth muscle function. We hypothesized that phasic contractions were greatest before birth. Bronchial muscle spontaneous rhythmic contractions were greatest in the fetus and absent in the adult. In response to KCl stimulation, the fetal bronchial smooth muscle only developed tonic force that was 3.5 +/- 0.6 and lower than measured in the newborn 9.0 +/- 0.3 and adult 13.7 +/- 1.4 mN/mm2. The thromboxane A2 analogue U46619 induced tonic and phasic muscle contractions and the amplitude and frequency of the phasic contractions were greater in the fetus as compared with the adult and increased with gestational age. The U46619-induced rhythmic contractions were abrogated by ryanodine, thapsigargin and reduction of extracellular Na+, suggesting intracellular Ca2+ dependence and involvement of the Na+/Ca2+ exchanger. The inward rectifier K+ blocker BaCl2 induced phasic contractions in unstimulated fetal...Continue Reading

References

Mar 1, 1979·Early Human Development·J S Wigglesworth, R Desai
Sep 1, 1991·Journal of Dental Research·S S GreenbergF A Curro
Oct 1, 1989·The American Journal of Physiology·E M GallantW E Rempel
Jun 1, 1988·British Journal of Pharmacology·T FujiwaraH Kuriyama
Nov 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C DavisE E Daniel
Apr 1, 1981·The Journal of Pediatrics·J S Wigglesworth
May 1, 1993·American Journal of Respiratory Cell and Molecular Biology·P B McCray
Jul 1, 1996·Journal of Applied Physiology·R Harding, S B Hooper
Sep 1, 1996·Experimental Physiology·V A SnetkovJ P Ward
Apr 17, 1998·Pediatric Research·V A SnetkovJ P Ward
Aug 12, 1998·European Journal of Anaesthesiology·T SatoS F Rabito
Jun 29, 2000·American Journal of Respiratory Cell and Molecular Biology·K T Nakamura, P B McCray
Jun 29, 2000·American Journal of Respiratory Cell and Molecular Biology·J C SchittnyM P Sparrow
Jun 16, 2001·Journal of Applied Physiology·K KobayashiJ J Greer
May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Luke J Janssen
Dec 12, 2003·Journal of Cardiovascular Pharmacology·James D Moffatt, Thomas M Cocks
Jan 27, 2004·American Journal of Respiratory and Critical Care Medicine·Wayne Mitzner
Oct 7, 2004·Journal of Muscle Research and Cell Motility·A V SomlyoA P Somlyo
Dec 4, 2004·American Journal of Respiratory Cell and Molecular Biology·Edwin C JesudasonPaul D Losty
May 14, 2005·American Journal of Respiratory Cell and Molecular Biology·Neil C FeatherstoneTheodor V Burdyga
Jun 21, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xueqin Ding, Paul A Murray
Sep 10, 2005·American Journal of Obstetrics and Gynecology·Mark WareingMichael J Taggart
Oct 11, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·J BelikMary D Pato

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Citations

Jul 10, 2007·Pediatric Surgery International·Edwin C Jesudason
Nov 12, 2010·Pediatric Surgery International·Toko ShinkaiPrem Puri
Aug 19, 2007·American Journal of Respiratory and Critical Care Medicine·Enrica FornaroJaques Belik
Jul 15, 2015·Journal of Theoretical Biology·Kishore K BokkaSharon R Lubkin
Nov 23, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jaques BelikSoenke Behrends
Apr 20, 2019·Journal of Engineering and Science in Medical Diagnostics and Therapy·Kimberley C W WangPeter B Noble
Apr 2, 2021·Development·Michael Donadon, Massimo M Santoro
Aug 27, 2021·Development·Michael Donadon, Massimo M Santoro

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