PMID: 6403172Mar 26, 1983Paper

Bronchial reactivity in asthmatic adults with normal spirometric values

British Medical Journal
T HigenbottamL Hill

Abstract

A comparison was made between airways obstruction produced by exercise. Hyperventilation of cold air, hyperventilation of room air, and inhalation of ultrasonically nebulised distilled water. Seven asthmatics with no airflow obstruction were studied together with seven normal controls. All four provocations produced comparable mean reductions in forced expired volume in one second in the asthmatic patients, but no reduction was obtained in the controls. Whereas exercise, hyperventilation of cold air, and hyperventilation of room air were associated with heat loss from airways, inhalation of nebulised distilled water was not. Inhalation of ultrasonically nebulised distilled water offers a simple additional diagnostic test for asthma. Changes in the osmolality of airway surface liquid may possibly be the common mechanism by which "fog" and hyperventilation produce bronchoconstruction.

References

Oct 4, 1979·The New England Journal of Medicine·E R McFadden, R H Ingram
Oct 1, 1975·The Journal of Allergy and Clinical Immunology·H ChaiR G Townley
Sep 1, 1973·The Journal of Allergy and Clinical Immunology·J B RichardsonD L Hall
Aug 1, 1981·Thorax·P M TweeddaleI W Grant
Mar 1, 1980·Respiration Physiology·L FerrusP Varene

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Citations

Jan 1, 1985·Allergy·R J ShawA B Kay
Aug 28, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M FujimuraT Matsuda
Jan 1, 1991·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C C LinC Y Lin
May 20, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G-J BraunstahlJ-B Prins

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