PMID: 2105190Feb 1, 1990Paper

Bronchial response to methacholine in "healthy" children of asthmatic parents. Effect of treatment with cromolyn sodium

Chest
I BrudermanJ Schachter

Abstract

Cumulative dose response curves to inhaled methacholine were established in 24 "healthy" children of asthmatic parents and 7 healthy children of healthy parents. Atopic children of asthmatic parents demonstrated higher bronchial hyperreactivity (BHR) than nonatopic children. The BHR was about ten times less than in the atopic parents of asthmatic children, indicating marked increase in BHR with age in atopic members of asthmatic families. Six weeks of treatment with cromolyn sodium (disodium cromoglycate) decreased BHR significantly (p less than 0.05) in eight atopic children, while no change occurred in BHR in five nonatopic children.

References

Jan 1, 1987·Archives of Disease in Childhood·R D CliffordS T Holgate
Apr 1, 1985·The Journal of Allergy and Clinical Immunology·O Löwhagen, S Rak
Jul 1, 1973·Archives of Disease in Childhood·P König, S Godfrey
May 1, 1981·The Journal of Allergy and Clinical Immunology·J G Easton
Sep 1, 1981·Clinical Allergy·J P Girard

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Citations

Jan 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A YuengsrigulE Nussbaum
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Johannes C van der WoudenFrancine Ducharme

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