PMID: 9551724Apr 29, 1998Paper

Bronchial responsiveness in active steelworkers

The European Respiratory Journal
J L CorhayM F Radermecker

Abstract

Coke-oven workers are exposed to dust and irritant gases. Therefore they are at risk of developing lung diseases including chronic bronchitis. Nonspecific bronchial hyperresponsiveness (BHR) has been advocated as a potential risk factor predisposing to the development of chronic bronchitis. In a previous study, we showed that prevalence of BHR was higher in retired coke-oven workers than in retired blast furnace workers. The present study was carried out to determine the prevalence of BHR in active steelworkers. Thus, 137 coke-oven workers and 150 blast furnace workers underwent clinical examination, a standardized questionnaire for the study of respiratory symptoms, pulmonary function testing and methacholine aerosol challenge. The study demonstrates a higher prevalence and degree of BHR [provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (PC20) < or = 8 mg x mL(-1)] in coke-oven workers than in blast furnace workers (31.4 versus 6.7%; p<0.001). Moreover, the frequency of respiratory symptoms and basal bronchial obstruction were greater among coke-oven workers with BHR in nonresponders. The basal maximum expiratory flow from 25-75% of forced vital capacity and the respiratory...Continue Reading

Citations

Jul 20, 2004·Occupational and Environmental Medicine·J WuC Darling
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·A A FryerM A Spiteri
Aug 27, 2002·Environmental Health Perspectives·George D Leikauf
Sep 22, 2000·Journal of Occupational and Environmental Medicine·A SobaszekJ L Edme
Sep 9, 2004·Journal of Occupational and Environmental Medicine·Jian WuChris Darling

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