Abstract
The main purpose of this review is to highlight mitochondria as a new therapeutic target to prevent bronchial smooth muscle (BSM) remodeling in asthma. Severe asthmatic patients, representing 5-10% of all asthmatics, are characterized by an increased BSM mass which is highly correlated with the severity of the disease and the rate of exacerbations. None of the current asthma therapies are effective in reducing BSM remodelling. This review, based on the current literature, reports the role of mitochondria in BSM, particularly in calcium signaling.
References
Sep 1, 1994·The Journal of Experimental Medicine·A L LazaarR A Panettieri
Jul 18, 2000·American Journal of Physiology. Cell Physiology·A OrtegaH Gonzalez-Serratos
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Carmela PepeQutayba Hamid
Feb 1, 2007·The European Respiratory Journal·E D FixmanJ G Martin
Dec 7, 2007·The Journal of Experimental Medicine·Thomas TrianPatrick Berger
Dec 17, 2008·Annals of the New York Academy of Sciences·Richard C Scarpulla
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Katharina MahnTak H Lee
Mar 9, 2010·Revue des maladies respiratoires·M-C DelmasUNKNOWN pour le groupe épidémiologie et recherche clinique de la SPLF
Apr 17, 2010·American Journal of Respiratory and Critical Care Medicine·David Ramos-BarbónJames G Martin
Nov 3, 2010·The European Respiratory Journal·I BaraP Berger
Jun 4, 2011·The Journal of Allergy and Clinical Immunology·Saleh Al-MuhsenQutayba Hamid
Dec 13, 2012·Frontiers in Physiology·John D Brannan, M Diane Lougheed
Dec 5, 2013·Molecular Cancer·Shanmugasundaram Ganapathy-Kanniappan, Jean-Francois H Geschwind
Mar 13, 2014·Current Pharmaceutical Design·Martine Uittenbogaard, Anne Chiaramello
Jan 31, 2015·American Journal of Respiratory and Critical Care Medicine·Pierre-Olivier GirodetPatrick Berger
Nov 6, 2015·American Journal of Respiratory and Critical Care Medicine·Pierre-Olivier GirodetPatrick Berger
Dec 22, 2015·The Journal of Allergy and Clinical Immunology·Thomas TrianPatrick Berger
Feb 15, 2017·JCI Insight·Sara C SebagIsabella M Grumbach
Mar 17, 2017·Journal of Neuroscience Research·P Andy LiShaocai Hao