Bronchiectasis in PCD looks different to CF on CT scan

Multidisciplinary Respiratory Medicine
Philip Robinson, Lucy Morgan

Abstract

The contemporary diagnosis of bronchiectasis requires CT scanning to describe specific structural lung changes. Scoring systems have been designed and validated in some specific causes of bronchiectasis to allow investigators to correlate CT changes with other indices of disease severity, to describe changes over time, with exacerbation and in response to treatment. Several scoring systems have been developed for CF including the Bhalla Score, Brody score, and the Helbich score. These scoring systems have also been applied to other causes of bronchiectasis including Primary Ciliary Dyskinesia (PCD). This assumes that the nature of structural lung disease in these conditions, as well as the rate and nature of longitudinal changes are identical to, or at least very similar to, those found in CF. This assumption has not been tested. The underlying pathophysiology of PCD is not the same as CF and may cause bronchiectasis that is radiologically similar but not necessarily the same as CF or any other cause of bronchiectasis. The development of a disease specific scoring system for structural change in cases of non-CF bronchiectasis due to any cause, would require consideration of the full range of changes seen in that condition witho...Continue Reading

References

Jun 1, 1991·Radiology·M BhallaD P Naidich
Jul 7, 1956·Journal of the American Medical Association·S J NICHAMIN
Apr 12, 2008·Chest·Francesca SantamariaPim A de Jong
Aug 13, 2008·Paediatric Respiratory Reviews·Barry LinnaneConor Murray
Apr 18, 2009·American Journal of Respiratory and Critical Care Medicine·Peter D SlyUNKNOWN Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST-CF)
Jun 10, 2010·The European Respiratory Journal·C E KuehniUNKNOWN ERS Task Force on Primary Ciliary Dyskinesia in Children
May 10, 2012·Pediatric Pulmonology·Marie Lémery MagninSylvain Blanchon
Nov 26, 2014·Pediatrics·Tara MullowneySharon Dell
Sep 30, 2015·Pediatric Pulmonology·Adam J ShapiroUNKNOWN Genetic Disorders of Mucociliary Clearance Consortium
Apr 14, 2017·Italian Journal of Pediatrics·Marco MaglioneFrancesca Santamaria

❮ Previous
Next ❯

Citations

Mar 15, 2019·Pediatric Pulmonology·Israel AmiravRonly H-E Cohn
Aug 29, 2018·Multidisciplinary Respiratory Medicine·Stefano Aliberti, James D Chalmers
Jun 5, 2020·ERJ Open Research·Cristina Ardura-GarciaClaudia E Kuehni
Nov 18, 2021·Journal of Paediatrics and Child Health·Loraine FabriPhilip Robinson

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

American Journal of Respiratory and Critical Care Medicine
Adam J ShapiroKathryn Briones
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
Yong-Xiang WeiDe-Min Han
American Journal of Respiratory and Critical Care Medicine
Samantha J IrvingAndrew Bush
© 2022 Meta ULC. All rights reserved