Bronchiectasis in severe asthma: Clinical features and outcomes

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Isabel ComanSantiago Quirce

Abstract

Bronchiectasis is increasingly being identified in patients with severe asthma and could contribute to disease severity. To determine the prevalence of bronchiectasis in a population of patients with severe asthma and to better characterize the clinical features of these patients and their outcomes. We retrospectively reviewed the medical files of 184 subjects with confirmed severe asthma who had undergone high-resolution thoracic computed tomography and compared the characteristics and outcomes of subjects with and without bronchiectasis. Bronchiectasis was identified in 86 patients (47%). These patients had concomitant hypersensitivity to nonsteroidal anti-inflammatory drugs (odds ratio [OR] 2.24, 95% confidence interval [CI] 1.00-5.03) and gastroesophageal reflux disease (OR 1.89, 95% CI 1.05-3.41) more frequently than subjects without bronchiectasis, but had less atopic dermatitis (OR 0.188, 95% CI 0.04-0.88). Subjects with bronchiectasis were more frequently hospitalized for asthma exacerbations (OR 2.09, 95% CI 1.08-4.05) and had higher blood eosinophil levels (464 vs 338; P = .005) than subjects without bronchiectasis. Our study suggests that in subjects with severe asthma, the presence of bronchiectasis is associated wi...Continue Reading

Citations

Nov 22, 2018·Current Opinion in Pulmonary Medicine·Javier Perez-MirandaEva Polverino
Dec 6, 2018·Current Opinion in Allergy and Clinical Immunology·Claudia CrimiNunzio Crimi
Oct 24, 2019·Current Opinion in Pulmonary Medicine·Paola RoglianiLuigino Calzetta
Feb 21, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Marta García-ClementeTeresa Gonzalez-Budiño
Apr 21, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Gema Sánchez-MuñozJavier de Miguel-Díez
Jun 20, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Gelei LanGuochao Shi
Dec 2, 2020·Journal of Clinical Medicine·Marta Garcia-ClementeMiguel Angel Martinez-García
Dec 2, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Sebastian FerriEnrico Heffler
Dec 4, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Elizabeth KudlatyAnju T Peters
Oct 27, 2020·Expert Review of Respiratory Medicine·Giacomo MalipieroEnrico Heffler
May 28, 2019·Respiratory Medicine·Jarkko MäntyläPaula Kauppi
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Holly R Keir, James D Chalmers
May 29, 2020·Respiration; International Review of Thoracic Diseases·Claudia CrimiNunzio Crimi

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