Bronchiectasis: new therapies and new perspectives

The Lancet. Respiratory Medicine
James D Chalmers, Sanjay H Chotirmall

Abstract

European Respiratory Society guidelines for the management of adult bronchiectasis highlight the paucity of treatment options available for patients with this disorder. No treatments have been licensed by regulatory agencies worldwide, and most therapies used in clinical practice are based on very little evidence. Development of new treatments is needed urgently. We did a systematic review of scientific literature and clinical trial registries to identify agents in early-to-late clinical development for bronchiectasis in adults. In this Review, we discuss the mechanisms and potential roles of emerging therapies, including drugs that target airway and systemic inflammation, mucociliary clearance, and epithelial dysfunction. To ensure these treatments achieve success in randomised clinical trials-and therefore reach patients-we propose a reassessment of the current approach to bronchiectasis. Although understanding of the pathophysiology of bronchiectasis is at an early stage, we argue that bronchiectasis is a heterogeneous disease with many different biological mechanisms that drive disease progression (endotypes), and therefore the so-called treatable traits approach used in asthma and chronic obstructive pulmonary disease coul...Continue Reading

Citations

Dec 1, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Vidya NavaratnamAnne B Chang
Jan 15, 2019·Current Opinion in Pulmonary Medicine·Emily G Kocurek, Rajani Jagana
Feb 12, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anne B Chang, Keith Grimwood
Feb 20, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jennifer K Quint, Maeve P Smith
Jun 8, 2018·Breathe·Celine VidaillacSanjay H Chotirmall
Sep 8, 2018·The European Respiratory Journal·Rita BoaventuraJames D Chalmers
Sep 29, 2018·American Journal of Respiratory and Critical Care Medicine·Micheál Mac AogáinSanjay H Chotirmall
Aug 14, 2019·Expert Review of Respiratory Medicine·Johnny WuDanielle F Wurzel
Dec 17, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sanjay H Chotirmall, Anne B Chang
Oct 18, 2019·The European Respiratory Journal·Jessica RademacherFelix C Ringshausen
Dec 21, 2019·American Journal of Respiratory and Critical Care Medicine·James D Chalmers, Oriol Sibila
Sep 6, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Hollian RichardsonJames D Chalmers
Dec 6, 2019·Breathe·Diego Severiche-BuenoSanjay H Chotirmall
Mar 27, 2020·American Journal of Respiratory and Critical Care Medicine·Pierre-Régis Burgel, Sanjay H Chotirmall
Sep 9, 2020·The New England Journal of Medicine·James D ChalmersUNKNOWN WILLOW Investigators
Jul 13, 2019·The European Respiratory Journal·David W Connell, Morven Wilkie
Jul 13, 2019·American Journal of Respiratory and Critical Care Medicine·Sanjay H Chotirmall
Apr 30, 2020·Clinical and Experimental Pharmacology & Physiology·Liyang LiYuanlin Song
Apr 17, 2020·Frontiers in Immunology·Luke A WallRicardo U Sorensen
Aug 29, 2018·Multidisciplinary Respiratory Medicine·Stefano Aliberti, James D Chalmers
May 24, 2018·BMC Pulmonary Medicine·Sanjay H Chotirmall, James D Chalmers
Nov 18, 2018·Nature Reviews. Disease Primers·James D ChalmersPamela J McShane
Jul 20, 2019·The European Respiratory Journal·Irena F Laska, James D Chalmers
Jul 11, 2019·Open Forum Infectious Diseases·Ruvandhi R NathavitharanaRocio M Hurtado
Sep 30, 2019·The European Respiratory Journal·Arietta Spinou, James D Chalmers
Nov 22, 2018·Particle and Fibre Toxicology·Tuang Yeow PohSanjay Haresh Chotirmall
May 22, 2019·American Journal of Respiratory and Critical Care Medicine·Oriol SibilaJames D Chalmers
Sep 24, 2020·The Clinical Respiratory Journal·Liyang LiChangzhou Shao
Dec 2, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Sebastian FerriEnrico Heffler
Dec 4, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Elizabeth KudlatyAnju T Peters
Oct 17, 2020·The Clinical Respiratory Journal·Pei Yee TiewSanjay H Chotirmall
Mar 20, 2021·Expert Review of Respiratory Medicine·Celine Vidaillac, Sanjay H Chotirmall
Apr 7, 2021·Nature Medicine·Micheál Mac AogáinSanjay H Chotirmall
Dec 1, 2020·Journal of Pediatric Surgery·Marion DurandNaziha Khen-Dunlop
Sep 26, 2020·The Korean Journal of Internal Medicine·Ho Cheol KimSei Won Lee
Jul 3, 2021·International Journal of Molecular Sciences·Martina OrianoStefano Aliberti
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Holly R Keir, James D Chalmers

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