Bronchiolar Adenoma: Expansion of the Concept of Ciliated Muconodular Papillary Tumors With Proposal for Revised Terminology Based on Morphologic, Immunophenotypic, and Genomic Analysis of 25 Cases.

The American Journal of Surgical Pathology
Jason C ChangNatasha Rekhtman

Abstract

We have identified 25 lesions involving alveolar lung parenchyma characterized by nodular proliferation of bland bilayered bronchiolar-type epithelium containing a continuous layer of basal cells. These lesions shared some histologic features with the recently described entity of ciliated muconodular papillary tumor (CMPT); however, the majority did not fit all diagnostic criteria in that they exhibited only focal or absent papillary architecture, and they had variable number of ciliated and mucinous cells, with some lesions entirely lacking 1 or both of these components. The morphologic and immunohistochemical features ranged from those resembling proximal bronchioles (proximal-type: moderate to abundant mucinous and ciliated cells; negative or weak TTF1 in luminal cells; n=8) to those resembling respiratory bronchioles (distal-type: scant or absent mucinous and ciliated cells; positive TTF1 in luminal cells; n=17). The hallmark of all lesions was a continuous layer of basal cells (p40 and CK5/6-positive). We provisionally designated these lesions as bronchiolar adenomas (BAs) and analyzed their clinicopathologic and molecular features. All BAs were discrete, sharply circumscribed lesions with a median size of 0.5 cm (range, 0...Continue Reading

References

Oct 1, 1990·The American Journal of Surgical Pathology·R R Miller
May 23, 2002·The American Journal of Surgical Pathology·Yasushi YatabeTakashi Takahashi
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Dec 18, 2003·Journal of the National Cancer Institute·Janet L MaldonadoBoris C Bastian
Sep 21, 2007·Nature Reviews. Cancer·Sophie SunAdi F Gazdar
Aug 19, 2008·The American Journal of Surgical Pathology·Shinsuke AidaSeiichi Tamai
Sep 2, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiromasa YamamotoTetsuya Mitsudomi
Apr 24, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jolien TolIris D Nagtegaal
Jun 4, 2010·Blood·Gayane Badalian-VeryBarrett J Rollins
Aug 21, 2010·Interactive Cardiovascular and Thoracic Surgery·Shuichi SatoAkira Yokoyama
Mar 23, 2011·Pathology International·Kentaro InamuraTamiko Takemura
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul K PaikGregory J Riely
Jun 15, 2011·The New England Journal of Medicine·Enrico TiacciBrunangelo Falini
Aug 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio MarchettiFiamma Buttitta
Jun 26, 2012·European Urology·Toni K ChoueiriSabina Signoretti
Nov 8, 2012·Pathology, Research and Practice·Lyska L Emerson, Lester J Layfield
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Dec 4, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T KinnoR Kushima
Mar 25, 2015·The American Journal of Surgical Pathology·Tsugumasa KamataKoji Tsuta
Jan 1, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tsugumasa KamataKoji Tsuta
Jan 31, 2016·Human Pathology·Kah Weng LauAngela Maria Takano
Jul 28, 2016·The American Journal of Surgical Pathology·Liping LiuJennifer M Boland
Oct 28, 2016·Pathology International·Tetsuo KonTetsuya Murata
Aug 24, 2017·Diagnostic Pathology·Emiko UdoJunya Fukuoka

❮ Previous
Next ❯

Citations

Feb 23, 2019·Thoracic Cancer·Xiaojun YaoLunxu Liu
Oct 30, 2019·General Thoracic and Cardiovascular Surgery·Han WangYan-Jiao Hu
Jan 30, 2020·Pathology International·Yuanyuan GuoJie Tong
Jul 28, 2020·International Journal of Surgical Pathology·Giulio RossiThomas Colby
Dec 15, 2020·American Journal of Clinical Pathology·Hemlata ShirsatNavneet Narula
Jan 6, 2021·The Journal of Pathology. Clinical Research·Jinchen ShaoJie Zhang
Jan 5, 2021·Journal of Surgical Case Reports·Ryohei MatsushimaHiroshi Yokomizo
Mar 17, 2021·Journal of Clinical Pathology·Yong YangHongcheng Liu
Feb 26, 2021·Histopathology·Katherine SyredAnnikka Weissferdt
Apr 26, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J H von der ThüsenR Cornelissen
May 8, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Rajesh VenkataramAnirban Chakraborty
May 15, 2021·Seminars in Diagnostic Pathology·Tzu-Hang Kao, Yi-Chen Yeh
Oct 8, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alain C Borczuk

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
biopsy

Software Mentioned

MSKCC
Torrent Variant Caller

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Tsugumasa KamataKoji Tsuta
© 2022 Meta ULC. All rights reserved