Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodeling

Seminars in Thoracic and Cardiovascular Surgery
Masaaki Sato, S Keshavjee

Abstract

Long-term success in lung transplantation continues to be challenged by chronic graft dysfunction, which is manifest as bronchiolitis obliterans syndrome (BOS). The mechanisms of BOS involve both immune-mediated pathways (rejection, autoimmune-like mechanisms), and alloimmune-independent pathways (infection, aspiration, ischemia, primary graft failure), which lead to a fibroproliferative responses. BOS correlates histologically with obliterative bronchiolitis in terminal bronchioles and evidence of aberrant remodeling in the airway epithelium, vasculature, stroma, and lymphoid system. A potentially important mechanism that supports the progressive and therapy-resistant nature of BOS is a continuous cycle of ongoing injury and aberrant remodeling. Namely, anatomical and functional abnormalities induce and exacerbate immune-mediated and alloimmune-independent pathways through various mechanisms (e.g., epithelial remodeling decreases mucociliary clearance that exacerbates aspiration-related injury). From this viewpoint, we review current therapeutic strategies and revisit the role of transplant surgeons in attenuating the initial transplant-related injuries to prevent the lung grafts from entering the remodeling-injury cycle.

Associated Clinical Trials

References

Sep 1, 1995·The Annals of Thoracic Surgery·R J KeenanB P Griffith
Aug 1, 1993·The Journal of Pharmacy and Pharmacology·K TakeyamaK Konno
Apr 1, 1996·American Journal of Respiratory and Critical Care Medicine·A T IaconoB P Griffith
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·T HirabayashiB Nashan
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·J ChesneyR Bucala
Aug 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·T J KroshusR M Bolman
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·A TanP B Bitterman
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·A N HusainE R Garrity
Oct 21, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A El-GamelI V Hutchinson
Dec 22, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G M VerledenM Demedts
Mar 10, 2001·Transplantation·J W van den BergW van der Bij
May 4, 2002·Nature Reviews. Molecular Cell Biology·James J TomasekRobert A Brown
May 23, 2002·Transplantation·Alain Le MoineDaniel Abramowicz
Jul 10, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S I ReznikT Mohanakumar
Aug 9, 2002·The European Respiratory Journal·L ZhengK W Tsang
Feb 13, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Barbara C CahillS V Karwande
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Marc de PerrotShaf Keshavjee
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Bruce A JohnsonSteven R Duncan
Jul 19, 2003·Clinical Transplantation·Denis HadjiliadisScott M Palmer
Nov 8, 2003·Chest·Lisa R YoungScott M Palmer
Dec 19, 2003·The European Respiratory Journal·A Boehler, M Estenne
Mar 31, 2004·The Journal of Thoracic and Cardiovascular Surgery·Kambiz SarahrudiWalter Klepetko
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Adam W Bingaman, Donna L Farber
Jun 3, 2004·Circulation·François Mach
Jan 8, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alin L GirnitaAdriana Zeevi
Jan 11, 2005·American Journal of Respiratory and Critical Care Medicine·Scott M PalmerDavid A Schwartz
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Andrew J FisherPaul A Corris
Mar 5, 2005·Trends in Immunology·Greg ParsonageChristopher D Buckley
Apr 7, 2005·Nature Medicine·Eric G Neilson
Apr 9, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Cristiano Feijó AndradeMingyao Liu
May 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Frank D'OvidioShaf Keshavjee
Jun 25, 2005·American Journal of Respiratory and Critical Care Medicine·Bryan YatesPaul A Corris
Sep 27, 2005·The Annals of Thoracic Surgery·Frank D'OvidioShaf Keshavjee

❮ Previous
Next ❯

Citations

Dec 17, 2009·General Thoracic and Cardiovascular Surgery·Ezequiel J MolinaMahender Macha
Nov 10, 2012·General Thoracic and Cardiovascular Surgery·Masaaki Sato
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mohammad A KhanMark R Nicolls
Jul 21, 2012·Interactive Cardiovascular and Thoracic Surgery·David J HallThomas M Beaver
Sep 25, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mohammad A KhanMark R Nicolls
Dec 25, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Daniel J Weber, David S Wilkes
Sep 21, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Srebrena AtanasovaVeronika Grau
Jun 26, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xinguo JiangMark R Nicolls
Sep 10, 2014·Transplant Immunology·K BuddingH G Otten
Feb 1, 2011·Seminars in Immunopathology·Rebecca A Shilling, David S Wilkes
Jan 29, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Jason H LeungShu S Lin
Aug 27, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y MatsudaC-W Chow
Dec 25, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masaaki SatoShaf Keshavjee
Feb 15, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masaaki SatoShaf Keshavjee
Sep 17, 2011·Revue de pneumologie clinique·F LemonnierE Rivaud
Nov 2, 2011·Thoracic Surgery Clinics·Toshitaka Hoppo, Blair A Jobe
Mar 23, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masaaki SatoShaf Keshavjee
Aug 12, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M SatoM Liu
Oct 1, 2009·Proteomics. Clinical Applications·Hossein MehraniLeila Golmanesh
Jun 13, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R A Shilling, D S Wilkes
Aug 14, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J-C ChangS S Lin
Oct 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T SaitoS Keshavjee
Apr 23, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Monika I SuwaraAndrew J Fisher
Jul 30, 2010·The Annals of Thoracic Surgery·Masaaki Sato, Thomas K Waddell
Feb 2, 2011·The American Journal of Pathology·Danny JonigkFlorian Laenger
Apr 26, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Cesare Perotti, Irena Sniecinski
Oct 22, 2013·The Journal of Surgical Research·Piero Marco Fisichella, Anahita Jalilvand
Dec 30, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L A BorthwickA J Fisher
Dec 17, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M PainUNKNOWN COLT Consortium
Jul 16, 2010·Virchows Archiv : an International Journal of Pathology·Danny JonigkFlorian Laenger
Jun 4, 2016·Transplantation·Pierre-Joseph RoyerUNKNOWN SysCLAD consortium
May 31, 2020·The European Respiratory Journal·Benedicte De MuynckUNKNOWN Leuven Lung Transplant Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
R A Shilling, D S Wilkes
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Marc EstenneS A Yousem
© 2022 Meta ULC. All rights reserved