PMID: 9557268Apr 29, 1998Paper

Bronchioloalveolar carcinoma: diagnostic pitfalls and immunocytochemical contribution

Diagnostic Cytopathology
H SalehW Sakr

Abstract

Because bronchioloalveolar carcinoma (BAC) commonly displays bland cytologic appearance, there is a good potential for misinterpretation. The aim of this study was twofold: one was to identify the most reproducible cytomorphologic features to distinguish BAC from conventional lung adenocarcinoma (CLA) on fine-needle aspiration (FNA), and the other was to investigate the staining characteristics of these two variants of lung carcinoma with P53 tumor suppressor gene immunostain and their potential value in the distinction between the two entities. Cytology records of 13 histologically documented BACs was retrieved: 7 FNA, 3 bronchial washing/bronchial brushing (BW/ BB), and 3 scraping smears of surgical specimens. Two cases had both FNA and BW/BB material. Immunostains for P53 protein, carcinoembryonic antigen (CEA), and Ki67(MIB-1) monoclonal antibodies were performed on 13 BACs (FNA cell blocks and tissue) and on 11 FNA cell blocks of CLA. Cytologically, BAC showed uniform cells with abundant, lacy cytoplasm, and bland, folded nuclei arranged singly, in papillary clusters, and sheets. Immunocytochemically, one BAC and one CLA were technically unacceptable. Of the 12 remaining BAC cases, 10 were reactive with CEA, 9 reactive wit...Continue Reading

Citations

Mar 17, 2010·Diagnostic Cytopathology·Viktor ShtilbansDavid E Burstein
Dec 19, 2001·Cancer·J P Crapanzano, M F Zakowski
Nov 8, 2001·Journal of the National Cancer Institute·M Palmarini, H Fan
Jul 8, 2010·Diagnostic Cytopathology·John P Crapanzano, Anjali Saqi
Mar 27, 2004·Archives of Pathology & Laboratory Medicine·G Peter SarantopoulosMichael C Fishbein

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