Broncho-alveolar lavage in sarcoidosis. Correlation between alveolar lymphocytosis and clinical data

Pathology, Research and Practice
A ArnouxJ Chretien

Abstract

Bronchoalveolar lavages (BAL) were performed in patients with pulmonary sarcoidosis and in normal subjects. In both smoking and nonsmoking sarcoid patients, the proportion and number of lymphocytes were significantly increased compared to corresponding controls (p less than 0.001 in each cases). BAL lymphocytes were identified as T lymphocytes (88 +/- 9% formed E rosettes). Neither the radiological stage, nor the duration of disease are related to the lymphocyte number. However, alveolar lymphocytosis is significantly correlated with clinical pattern (p less than 0.02) and with clinical extrathoracic dissemination (p less than 0.001). Black patients have significantly more disseminated disease than Whites (p less than 0.001). The lymphocytosis of the bronchoalveolar space is associated with the presence of granulomas in bronchial biopsies (p less than 0.005). For clinical purposes, the results of BAL were helpful in determining the evolutivity of the disease, particularly progression to stage III. Together with a high lymphocyte count, a significant increase of all the polymorphonuclear leukocytes (PMNL) was found in stage III (4.0 +/- 4.6 X 10(4) PMNL/ml, p less than 0.001) compared to earlier stages (respectively 0.6 +/- 0.5 ...Continue Reading

References

Jan 1, 1976·Annals of the New York Academy of Sciences·D G JamesL E Siltzbach

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Citations

Sep 20, 1991·Journal of Immunological Methods·T van MaarsseveenE Laake
Jul 2, 1983·Lancet·A VenetJ Leibowitch
Mar 1, 1983·Thorax·B H Davies
Oct 1, 1986·Clinics in Dermatology·T Izumi
Jan 1, 1986·Annals of the New York Academy of Sciences·F ClavelJ Chrétien
Jan 1, 1986·Annals of the New York Academy of Sciences·A G ArnouxJ Chrétien

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