PMID: 8470343Mar 1, 1993Paper

Bronchoalveolar eosinophilic cells in a canine model of asthma: two distinctive populations

Veterinary Pathology
F Baldwin, A B Becker

Abstract

In a canine model of asthma, the identity and relationships of two types of cells with eosinophilic granules found in bronchoalveolar lavage (BAL) were investigated. Five female and three male newborn mongrel dogs were sensitized by intraperitoneal injection of 500 micrograms ragweed in 30 mg aluminum hydroxide repeated weekly for 8 weeks and then biweekly until 16 weeks of age. Three female and two male littermate controls received 30 mg aluminum hydroxide. From 4 months of age, dogs received six breaths of wet-nebulized ragweed solution through an endotracheal tube bimonthly. Bronchoalveolar lavage was performed 2 months or more after the last exposure to ragweed and was repeated 5 hours after ragweed inhalation. Dogs studied were 15 to 38 months of age. Eosinophilic cell populations were determined in BAL and peripheral blood; cells were examined by light and electron microscopy. Two eosinophilic cell types were in BAL: an eosinophil and an atypical cell with globule leukocyte characteristics. Specific microgranules, a constant feature of eosinophils, were prominent in the atypical cell and suggest a relationship to the eosinophil granulocyte series for the atypical cell and cells identified by others as globule leukocytes. ...Continue Reading

References

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Citations

Jul 7, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S YangC McCall
May 22, 1998·Journal of Veterinary Internal Medicine·J E Hare, L Viel
Nov 5, 2008·Journal of the American Animal Hospital Association·Sandrine DehardCecile Clercx
Aug 5, 2015·Cell and Tissue Research·Grace AmpemTamás Röszer
May 25, 2012·Reproduction in Domestic Animals = Zuchthygiene·H KliemD Schams
Feb 20, 2003·Proceedings. Biological Sciences·Corwin SullivanRoger M H Smith
Jan 14, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mathieu G Faure-Brac, Jorge Cubo

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