Bronchoalveolar inflammation following airway infection in preterm infants with chronic lung disease

Pediatric Pulmonology
P GroneckChristian P Speer

Abstract

Chronic lung disease (CLD) of the newborn is associated with pulmonary inflammation. However, the origin of this inflammation is not known. We evaluated the impact of airway infection on bronchoalveolar inflammation in mechanically ventilated preterm infant at risk for CLD (n = 68). Mean and maximum concentrations of the inflammatory mediators (IM) interleukin-1 and interleukin-8 were assayed in the tracheobronchial aspirate fluid (TAF) of neonates with perinatal airway infection (Ureaplasma urealyticum, or bacteria), postnatal nosocomial airway infection, or respiratory disease without airway infection from days 1-10 of postnatal age. Patients with CLD (n = 23;) exhibited increased levels of IM in TAF compared to neonates without CLD. Within the three subgroups, concentrations of IM were increased in CLD patients with perinatal infection and in CLD patients with respiratory disease without airway infection, but not in CLD patients with nosocomial airway infection. Although airway colonization with Gram-negative bacteria was more frequently found in CLD patients within the first month of life, there were no differences between levels of IM in patients colonized with Gram-negative bacteria or coagulase-negative staphyloccoci. We...Continue Reading

Citations

Dec 5, 2003·Molecular Genetics and Metabolism·Tarah T ColaizyDe-Ann M Pillers
Apr 2, 2003·Seminars in Neonatology : SN·Christian P Speer
Feb 26, 2004·Paediatric Respiratory Reviews·Christian P Speer
Oct 15, 2005·Clinical Microbiology Reviews·Ken B WaitesRobert L Schelonka
Sep 14, 2002·Infection and Immunity·Rose M ViscardiJeffrey D Hasday
Jan 9, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P V MohanA Cust
Apr 21, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·C P Speer
Jun 18, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·B W Kramer
Jan 13, 2015·Expert Review of Anti-infective Therapy·Kirsten Glaser, Christian P Speer
Oct 27, 2007·Revista portuguesa de pneumologia·Gustavo RochaHercília Guimarães
Apr 2, 2008·Developmental and Comparative Immunology·Shanjana AwasthiKevin M Brown
Feb 24, 2007·Seminars in Perinatology·Robert L Schelonka, Ken B Waites
Feb 6, 2007·The Journal of Hospital Infection·Imad R MakhoulUNKNOWN Israel Neonatal Network
May 17, 2006·Seminars in Fetal & Neonatal Medicine·Christian P Speer
Dec 14, 2016·Journal of Cellular and Molecular Medicine·Ina RudloffClaudia A Nold-Petry
Aug 19, 2003·The Annals of Pharmacotherapy·Pamela D ReiterRobert J Valuck
Oct 2, 2003·Pediatric Pulmonology·Steven L OlsenWilliam E Truog
Apr 29, 2006·Current Opinion in Infectious Diseases·Georgia S PinnaDimitris A Kafetzis
Sep 12, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Miho SatoShumpei Yokota
Jan 2, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Fook-Choe CheahSuhas G Kallapur
Sep 19, 2017·Expert Review of Clinical Immunology·Christine SilwedelKirsten Glaser

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