Abstract
Asthma is a complex heterogeneous disease occurring in adults and children that is characterized by distinct inflammatory patterns. While numerous studies have been performed in adults, little is known regarding the heterogeneity of severe asthma in children, particularly inflammatory signatures involving the air spaces. We sought to determine the relationship of bronchoalveolar lavage (BAL) cytokine/chemokine expression patterns in children with severe therapy-resistant asthma stratified according to neutrophilic versus nonneutrophilic BAL inflammatory cell patterns. Children with severe asthma with inadequate symptom control despite therapy underwent diagnostic bronchoscopy and BAL. Inflammatory cytokine/chemokine concentrations were determined using a multiplex protein bead assay. Analysis of BAL constituents with an unbiased clustering approach revealed distinct cytokine/chemokine patterns, and these aligned with pathways associated with type 2 innate lymphoid cells, monocytes, neutrophil trafficking, and T effector cells. All cytokines examined (n = 27) with 1 exception (vascular endothelial growth factor) were overexpressed with BAL neutrophilia compared with nonneutrophilic asthma, and this was confirmed in a cross-valid...Continue Reading
References
May 1, 1989·The Journal of Allergy and Clinical Immunology·H BoeyL Borish
Jun 16, 2000·The Journal of Allergy and Clinical Immunology·N N JarjourW W Busse
May 12, 2001·Chest·P G GibsonN Saltos
Jan 1, 1950·Cancer·W J YOUDEN
May 16, 2008·American Journal of Respiratory and Critical Care Medicine·Pranab HaldarRuth H Green
Apr 8, 2010·The Journal of Allergy and Clinical Immunology·Anne M FitzpatrickUNKNOWN National Institutes of Health/National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Apr 20, 2010·The Journal of Allergy and Clinical Immunology·Annette T HastieUNKNOWN National Heart, Lung, and Blood Institute Severe Asthma Research Program
Oct 15, 2011·PLoS Pathogens·Ama-Tawiah EssilfiePhilip M Hansbro
Dec 18, 2013·The Journal of Allergy and Clinical Immunology·Wendy C MooreUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Jun 24, 2014·PloS One·Benjamin J GreenPeter H Howarth
Nov 18, 2015·JAMA : the Journal of the American Medical Association·Leonard B BacharierFernando D Martinez
Jul 22, 2016·Immunity·Janine WoytschakOnur Boyman
Oct 18, 2016·The Journal of Allergy and Clinical Immunology·Cecilia K AnderssonClare M Lloyd
Dec 7, 2016·American Journal of Respiratory and Critical Care Medicine·Nicholas J Gross, Peter J Barnes
Feb 7, 2017·The Journal of Allergy and Clinical Immunology·Rafeul AlamRichard J Martin
Apr 2, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Tamazoust GuiddirJocelyne Just
Sep 25, 2017·The Journal of Allergy and Clinical Immunology·Julia A WisniewskiJudith A Woodfolk
Jan 18, 2019·The Journal of Allergy and Clinical Immunology. in Practice·W Gerald TeagueLarry Borish
Feb 16, 2019·The Journal of Allergy and Clinical Immunology·Daniela ImpellizzieriOnur Boyman
Citations
Jul 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Ryan C MurphyMatthew C Altman
Aug 28, 2021·International Journal of Molecular Sciences·Marina Ruxandra OteleaAgripina Rascu
Aug 16, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Monica G LawrenceLarry Borish
Sep 7, 2021·Frontiers in Immunology·Sharon Van NevelOlga Krysko
Oct 29, 2021·Expert Review of Respiratory Medicine·Sarah van den BergBerber Kapitein
Nov 29, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Andy BushStanley J Szefler