Bronchoalveolar lavage desmosine in bleomycin-induced lung injury in marmosets and patients with adult respiratory distress syndrome.

Experimental Lung Research
S IdellB C Starcher

Abstract

Measurement of urinary desmosine in experimental models of emphysema has been used to demonstrate elastin catabolism. In order to evaluate the hypothesis that accelerated elastin degradation also occurs in association with acute lung injury characterized by fibrotic repair, we prepared acid hydrolysates of lung lavage (LL) and used a radioimmunoassay for desmosine to measure concentrations of this elastic-specific cross-link in LL. Lavage desmosine (pmol/100 microliter LL) was measured following bleomycin-induced lung injury in marmosets and was shown to be elevated at 1 week (median 6.0, range 5.1-7.8), 2 weeks (8.4, 6.2-8.7), and 4 weeks (7.6, 4.8-7.8) compared to control levels (1.8, 1.4-3.7). Elevations of lavage desmosine after bleomycin were temporarily associated with remodeling of the lung as indicated by increased total lung collagen, reduced diffusing capacity and lung compliance, and histologic evidence of pulmonary fibrosis. Bronchoalveolar lavage (BAL) desmosine was measured in patients with the Adult Respiratory Distress Syndrome (ARDS) and compared with patients at risk, patients with other interstitial lung diseases, and normal healthy controls. BAL desmosine (pmol/100 microliters) was not significantly differen...Continue Reading

References

Jan 1, 1978·Lung·C Kuhn, R M Senior
Jun 1, 1976·Journal of Applied Physiology·K W KooG L Snider
Apr 1, 1985·The American Review of Respiratory Disease·M C BruceA A Fanaroff
Jan 1, 1980·Connective Tissue Research·G S KingB C Starcher
May 1, 1983·The American Review of Respiratory Disease·A JanoffR Dearing
Jan 22, 1981·The New England Journal of Medicine·C T LeeG Weinbaum
May 1, 1981·Metabolism: Clinical and Experimental·S Y YuV H Ayvazian
Nov 1, 1980·The American Review of Respiratory Disease·S HarelE H Bergofsky
Dec 1, 1978·Lung·Charles Kuhn, Robert M Senior

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Citations

Jan 1, 1991·Annals of the New York Academy of Sciences·R A MumfordK Hand
Mar 3, 2010·American Journal of Respiratory and Critical Care Medicine·Sreerama ShettyRashmi S Shetty
Feb 18, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·J A FillB G Zeiher
Oct 6, 2000·Clinics in Chest Medicine·D H Ingbar
Nov 22, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Takaji SatoSonoko Nagai
Jun 25, 2003·British Journal of Anaesthesia·S V Baudouin
Jul 27, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robin RoychaudhuriCaroline A Owen
Feb 14, 2019·Critical Care : the Official Journal of the Critical Care Forum·Yishan WangZhaohui Tong
Sep 2, 2018·Respiratory Research·Pedro AyalaGisella R Borzone

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