Bronchoalveolar lavage fluid D dimer levels are higher and more prevalent in black patients with pulmonary sarcoidosis

Respiration; International Review of Thoracic Diseases
Rafael L PerezEmory Interstitial Lung Disease Center

Abstract

Abnormalities of lung coagulation and fibrinolysis in sarcoidosis are thought to play a role in the pathogenesis of this disease. We previously showed that bronchoalveolar lavage fluid (BALF) D dimer directly correlated with various measures of severity in sarcoidosis. Here, we analyze our observation that BALF D dimer was more frequently found at higher levels in African-American patients with pulmonary sarcoidosis. BALF D dimer was measured in 55 subjects with pulmonary sarcoidosis and 31 healthy volunteers by enzyme immunoassay. The healthy group established a normal range of BALF D dimer with 71 ng/ml as the highest measured level. This was the cut point for comparisons among the patients with sarcoidosis. High BALF D dimer levels (>71 ng/ml) were found in younger patients with sarcoidosis and were associated with a significantly lower percent predicted forced expiratory volume in 1 s and greater numbers of BAL lymphocytes. Black patients with sarcoidosis had higher BALF D dimer levels (median 131, range 0-2,040 ng/ml) than white patients (median 18, range 0-605 ng/ml; p = 0.011). Higher than normal BALF D dimer levels were found in 61% of the black subjects with sarcoidosis, but in only 20% of the white individuals (chi(2)...Continue Reading

References

Jan 1, 1992·Neurological Research·K J GainesC Cape
Mar 15, 1990·Thrombosis Research·B NakstadN P Boye
Dec 1, 1989·The American Review of Respiratory Disease·C KuhnJ A McDonald
Mar 1, 1986·The Journal of Clinical Investigation·R M SeniorG D Wilner
Jun 27, 1983·Annals of the New York Academy of Sciences·R B Colvin
Oct 1, 1995·Southern Medical Journal·S Nagai, T Izumi
Sep 1, 1995·The Journal of Clinical Investigation·M A OlmanD J Loskutoff
Aug 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·A J LeeA Rumley
Jul 1, 1994·American Heart Journal·S KimuraK Shimada
Feb 1, 1997·American Journal of Epidemiology·B A RybickiM C Iannuzzi
Apr 24, 1997·The New England Journal of Medicine·L S NewmanL A Maier
Feb 5, 2000·American Journal of Respiratory Cell and Molecular Biology·M D Nguyen, P J Simpson-Haidaris
Apr 18, 2000·Chest·A F Shorr, O W Hnatiuk
May 8, 2000·Journal of Applied Physiology·P J van den BurgI A Huisveld
Oct 12, 2000·The American Journal of Cardiology·S D FisherUNKNOWN THROMBO Investigators
Nov 15, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·C F PieperH J Cohen
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·R P BaughmanUNKNOWN Case Control Etiologic Study of Sarcoidosis (ACCESS) research group
Dec 6, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J W YarnellG D Lowe
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Hajime FujimotoOsamu Taguchi
Jun 11, 2003·American Journal of Respiratory and Critical Care Medicine·Robert M Strieter

❮ Previous
Next ❯

Citations

Jul 8, 2009·Inflammation·Elena BargagliPaola Rottoli
Jun 10, 2008·Clinics in Chest Medicine·E BargagliPaola Rottoli
Mar 14, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Samantha M YeligarLou Ann S Brown

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Related Papers

American Journal of Respiratory and Critical Care Medicine
H KobayashiY Adachi
Current Opinion in Pulmonary Medicine
Gianpietro SemenzatoCarlo Agostini
Clinics in Chest Medicine
U Costabel, H Teschler
© 2021 Meta ULC. All rights reserved