Abstract
Diagnosing chronic pulmonary aspergillosis (CPA) is complicated, and there are limited data available regarding the identification of galactomannan (GM) in clinical specimens to assist the detection of this infection. The purpose of this study was to evaluate the detection of GM in bronchoalveolar lavage fluid (BALF) and serum and to assess its utility for diagnosing CPA. We retrospectively reviewed the diagnostic and clinical characteristics of 144 patients, with and without CPA, in Nagasaki University Hospital, Japan, whose BAL and serum specimens were examined for the presence of GM. The Platelia Aspergillus enzyme immunoassay (PA EIA) was performed according to the manufacturer's instructions. The mean values of BALF GM antigen were 4.535 (range, 0.062-14.120) and 0.430 (range, 0.062-9.285) in CPA (18) and non-CPA (126) patients, respectively. The mean values of serum GM antigen were 1.557 (range, 0.232-5.397) and 0.864 (range, 0.028-8.956) in CPA and non-CPA patients, respectively. PA EIA of BALF is superior to the test with serum, with the optimal cut-off values for BALF and serum of 0.4 and 0.7, respectively. The sensitivity and specificity of PA EIA in BALF at a cut-off of 0.4 were 77.2% and 77.0%, respectively, whereas...Continue Reading
References
Mar 1, 1982·Medicine·R E BinderG L Snider
Aug 1, 1981·Radiology·W B GefterW T Miller
Jan 1, 1997·Journal of Clinical Microbiology·C M SwaninkP E Verweij
Aug 1, 1997·Chest·J L SaracenoD B Schwartz
Oct 31, 2000·Scandinavian Journal of Infectious Diseases·J SalonenJ Nikoskelainen
Aug 30, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D W Denning
Apr 29, 2003·British Journal of Haematology·Martin J BeckerSiem De Marie
Aug 9, 2003·Journal of Clinical Microbiology·Maurizio SanguinettiGiovanni Fadda
Sep 17, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W DenningHelen Sambatakou
Mar 5, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claudio ViscoliAndrea Bacigalupo
Apr 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Shahid HusainNina Singh
Nov 6, 2004·Journal of Clinical Microbiology·Daniele MatteiAndrea Gallamini
Dec 8, 2004·Journal of Clinical Microbiology·Benjamin MusherKieren A Marr
Aug 23, 2005·Medical Mycology·W W HopeD W Denning
Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher D PfeifferNasia Safdar
Sep 22, 2007·American Journal of Respiratory and Critical Care Medicine·Wouter MeerssemanEric Van Wijngaerden
Apr 21, 2009·Clinics in Chest Medicine·Kenneth S Knox, Laura Meinke
Aug 8, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yasuhiko KitasatoHisamichi Aizawa
Nov 17, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hae-Seong NamWon-Jung Koh
Jul 3, 2010·The European Respiratory Journal·N L Smith, D W Denning
Aug 28, 2010·The Journal of Infection·Shigeru KohnoUNKNOWN Japan Chronic Pulmonary Aspergillosis Study Group (JCPASG)
Sep 10, 2010·Current Opinion in Infectious Diseases·Koichi IzumikawaShigeru Kohno
Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Seong Yeon ParkSung-Han Kim
Citations
Jul 10, 2013·Medical Mycology·Byung Woo JhunWon-Jung Koh
Apr 10, 2014·Biomarkers in Medicine·Gemma JohnsonStephen A Bustin
Feb 18, 2016·Respiratory Investigation·Koichi Izumikawa
May 27, 2014·Clinics in Laboratory Medicine·Frédéric Lamoth, Barbara D Alexander
Dec 5, 2013·Mycoses·K E SchweerO A Cornely
May 12, 2015·Mycoses·Ritesh AgarwalArunaloke Chakrabarti
Jan 28, 2014·The Journal of Infection·Beomsu ShinKyeongman Jeon
May 23, 2014·The Journal of Infection·M PeghinA Pahissa
Dec 3, 2016·Mycoses·Helmut J F SalzerChristoph Lange
Jul 12, 2017·Journal of Medical Microbiology·Mojtaba Taghizadeh-ArmakiSeyedmojtaba Seyedmousavi
Jun 6, 2018·PloS One·Katsuhiro YoshimuraTakafumi Suda
Jun 20, 2018·Mycoses·Inderpaul Singh SehgalRitesh Agarwal
Mar 24, 2017·Journal of Clinical Microbiology·Naohisa UrabeSakae Homma
Sep 8, 2018·The Clinical Respiratory Journal·Yake YaoJianying Zhou
Dec 18, 2018·Expert Review of Anti-infective Therapy·Jeffrey D JenksMartin Hoenigl
Jan 11, 2019·Journal of Clinical Microbiology·Inderpaul Singh SehgalRitesh Agarwal
Dec 25, 2015·The European Respiratory Journal·David W DenningUNKNOWN European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society
May 21, 2019·The Cochrane Database of Systematic Reviews·Koen de HeerMariska Mg Leeflang
Aug 8, 2019·BMC Infectious Diseases·Xiuqing MaLixin Xie
Apr 16, 2020·BMC Pulmonary Medicine·Qihong YuHaiying Peng
Mar 8, 2019·Journal of Clinical Microbiology·Takahiro TakazonoKoichi Izumikawa
May 10, 2020·Mycoses·Maryam GheisariMohammad Taghi Hedayati
Dec 13, 2012·Annals of the New York Academy of Sciences·Emmanuel Roilides, Zoi-Dorothea Pana
Jul 18, 2018·Emerging Infectious Diseases·David W DenningHaileyesus Getahun
Jun 7, 2016·Journal of Fungi·Gemma E Hayes, Lilyann Novak-Frazer
Oct 20, 2018·Frontiers in Microbiology·Helmut J F SalzerMartin Hoenigl
Dec 5, 2016·Medical Mycology·Chris Kosmidis, Eavan G Muldoon
Sep 4, 2018·Frontiers in Microbiology·Takahiro Takazono, Koichi Izumikawa
Oct 8, 2017·Der Internist·H J F SalzerM Hönigl
Dec 19, 2020·BioMed Research International·Xun-Jie CaoXu-Guang Guo
Mar 29, 2020·Respiratory Medicine·Min LangAmanjit Gill