PMID: 697224Oct 1, 1978Paper

Bronchoalveolar lavage in interstitial lung disease

Annals of Internal Medicine
S E WeinbergerR G Crystal

Abstract

Cellular and immunoglobulin components of bronchoalveolar fluid recovered by bronchoscopic lavage were evaluated in 32 control patients, 10 normal volunteers, and 60 patients with the following interstitial lung diseases: idiopathic pulmonary fibrosis, pulmonary fibrosis associated with collagen-vascular disease, eosinophilic granuloma, sarcoidosis, and hypersensitivity pneumonitis. The percentage of lymphocytes distinguished two general disease categories: those with increased lymphocytes (sarcoidosis and hypersensitivity pneumonitis); and those with normal lymphocytes (idiopathic pulmonary fibrosis, pulmonary fibrosis associated with collagen-vascular disease, and eosinophilic granuloma). Patients in all five disease categories had elevated IgG levels and percentages of neutrophils compared with control patients, with the highest proportion of neutrophils found in idiopathic pulmonary fibrosis. Immunoglobulin levels also helped distinguish among patient groups, in that patients with hypersensitivity pneumonitis had lavage IgG/albumin ratios greater than 1, whereas patients with sarcoidosis had ratios less than 1; and with infrequent exceptions, the finding of IgM in lavage fluid was limited to patients with hypersensitivity p...Continue Reading

Citations

Aug 1, 1986·Clinical Reviews in Allergy·M Lopez, J E Salvaggio
Feb 12, 2008·Intensive Care Medicine·Claudia C Dos Santos
Nov 15, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·T SatoM Masada
Sep 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·T SatoS Nagai
Mar 22, 2001·Advanced Drug Delivery Reviews·U B Kompella, V H Lee
Jun 7, 1979·The New England Journal of Medicine·M SchatzJ Fink
Oct 4, 1979·The New England Journal of Medicine·J E GadekR G Crystal
Mar 13, 1980·The New England Journal of Medicine·G W HunninghakeR G Crystal
May 22, 1980·The New England Journal of Medicine·E C LawrenceP M Stevens
Jan 7, 1982·The New England Journal of Medicine·G SemenzatoG Pizzolo
May 22, 1986·The New England Journal of Medicine·P B BittermanR G Crystal
Jan 1, 1988·The American Review of Respiratory Disease·A J HanceR G Crystal
Jan 1, 1988·The American Review of Respiratory Disease·M W PetersonG W Hunninghake
Aug 1, 1988·The American Review of Respiratory Disease·M LavioletteR Coulombe
Nov 1, 1988·The American Review of Respiratory Disease·C F PantinM Turner-Warwick
Aug 1, 1992·The American Review of Respiratory Disease·R K MerchantG W Hunninghake
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Mar 4, 2008·Biological & Pharmaceutical Bulletin·Takaji SatoSonoko Nagai
Jan 1, 1987·Thorax·A S RobertsonM H Carmalt
May 1, 1985·Thorax·R M du Bois
Mar 1, 1984·Postgraduate Medical Journal·D P Dhillon, J V Collins
Jun 1, 1984·Environmental Health Perspectives·R F Henderson
Sep 1, 1980·The Journal of Clinical Investigation·G W HunninghakeR G Crystal
Aug 2, 1980·British Medical Journal·D M MitchellJ V Collins
Jan 1, 1982·Thorax·B A Keogh, R G Crystal
Jul 1, 1981·The Journal of Clinical Investigation·G W HunninghakeR G Crystal

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