PMID: 2117104Jan 1, 1990Paper

Bronchoalveolar lavage in the diagnosis of cancer

Lung
S I Rennard

Abstract

Bronchoalveolar lavage (BAL) is a widely used clinical procedure. To determine if BAL could provide useful information in the detection of cancer, 850 lavages from 421 patients having BAL for a variety of indications, 50 lavages in patients with Hodgkin's disease and 20 patients with breast cancer undergoing bone marrow transplant were reviewed. BALs were performed with 5 successive 20 cc aliquots in a wedged position. The return from the first aliquot was processed separately from the subsequent four aliquots. Diff-Quik stained cytocentrifuge preparations and Papanicolaou stained millipore filter preparations were analyzed. Thirty-five patients had biopsy-proven lung cancer. In 24 (68.6%) of these, BAL revealed cells diagnostic of malignancy. There were no false positives. Six out of 50 Hodgkin's disease patients had Reed Sternberg cells detected on BAL, and 7/20 breast cancer patients had malignant cells on BAL prior to chemotherapy. In summary, the routine performance of BAL, an easily performed and well-tolerated procedure, may prove to be useful in the routine assessment of patients for cancer.

References

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Citations

Mar 31, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·J Rodríguez FloresM J Rodríguez Gómez
Oct 7, 2000·Respirology : Official Journal of the Asian Pacific Society of Respirology·B LamK W Tsang
Mar 1, 1992·Mayo Clinic Proceedings·R J Pisani, A J Wright
Feb 23, 2010·Clinics in Chest Medicine·Felix J F Herth, Ralf Eberhardt
Dec 19, 2006·Diagnostic Cytopathology·Sukant GargAshok K Janmeja
Apr 17, 1999·Clinics in Chest Medicine·R P Baughman, E M Pina
Feb 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Fariba BineshAli Akhavan
Oct 19, 2016·Diagnostic Cytopathology·Claire W MichaelN Paul Ohori
Feb 18, 2003·Scandinavian Journal of Immunology·D MatanićF Milevoj-Ribić

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