PMID: 14208195Aug 1, 1964

BRONCHOCONSTRICTOR ACTION AND ANTAGONISM OF A SLOW-REACTING SUBSTANCE FROM ANAPHYLAXIS OF GUINEA-PIG ISOLATED LUNG

British Journal of Pharmacology and Chemotherapy
P A BERRY, H O Collier

Abstract

Slow-reacting substance produced in anaphylaxis (SRS-A) increased resistance of the lungs to inflation in the guinea-pig in vivo and caused isolated preparations of its tracheobronchial muscle to contract. SRS-A also contracted human isolated bronchial muscle and some but not all preparations of rabbit trachea. Nonsteroid anti-inflammatory drugs, which antagonize bronchoconstriction induced by kinins, but not that by histamine, acetylcholine, 5-hydroxytryptamine, substance P, angiotensin or lung prostaglandin, also antagonized the bronchoconstrictor action of SRS-A. This antagonism resembled that of kinins in being surmounted by higher doses of agonist, in the potencies of active drugs and in the types of drugs which were inactive. However, receptors in guinea-pig tracheobronchial muscle for SRS-A seem to be distinct from those for bradykinin, since preparations of this muscle could become unresponsive to either agent in vivo and in vitro, while remaining responsive to the other.

References

Dec 1, 1960·British Journal of Pharmacology and Chemotherapy·H O Collier, P G SHORLEY
Jun 1, 1960·British Journal of Pharmacology and Chemotherapy·H O CollierP G SHORLEY
Aug 1, 1962·British Journal of Pharmacology and Chemotherapy·K D BHOOLAP G SHORLEY
Dec 16, 1961·Nature·H HERXHEIMER, E STRESEMANN
Apr 1, 1963·British Journal of Pharmacology and Chemotherapy·H O Collier, P G SHORLEY
Feb 4, 1963·Annals of the New York Academy of Sciences·H O Collier
Oct 12, 1963·Nature·H O CollierB WHITELY

Citations

Jan 15, 1972·Experientia·B B Vargaftig, Nguyen-dao-Hai
Jul 1, 1977·Agents and Actions·N Chand, P Eyre
Oct 1, 1979·Agents and Actions·K Forsberg, L Sörenby
Jul 1, 1976·Agents and Actions·P J Piper
Dec 1, 1981·Agents and Actions·B B VargaftigR C Murphy
Jul 1, 1981·Agents and Actions·D M RitchieM E Rosenthale
Sep 1, 1976·European Journal of Pharmacology·A G Herman, J R Vane
Jul 15, 1977·European Journal of Pharmacology·J F Burka, P Eyre
Feb 15, 1979·European Journal of Pharmacology·H W Mitchell, M A Denborough
Oct 1, 1979·European Journal of Pharmacology·B B VargaftigF Fouque
Apr 9, 1981·European Journal of Pharmacology·J F Burka, N A Paterson
Sep 11, 1981·European Journal of Pharmacology·B B Vargaftig, J Lefort
May 7, 1982·European Journal of Pharmacology·A PrancanB B Vargaftig
Aug 27, 1982·European Journal of Pharmacology·C L ArmourR R Schellenberg
Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·D G BadenI Leung
Jul 1, 1991·Immunopharmacology·S G Farmer
Jan 1, 1989·Pharmacology & Therapeutics·P J Gardiner
Jan 1, 1987·International Journal of Immunopharmacology·L J RobichaudR L Adolphson
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·M N Samhoun, P J Piper
Jan 1, 1977·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·P J Piper
Jun 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Bochnowicz, D C Underwood
Apr 1, 1975·British Journal of Haematology·J R O'Brien
Jun 1, 1967·British Journal of Pharmacology and Chemotherapy·H O Collier, G W James
Feb 1, 1968·British Journal of Pharmacology and Chemotherapy·H O CollierC Schneider
Mar 1, 1973·British Journal of Pharmacology·P EyreP W Wells
Jul 1, 1976·British Journal of Pharmacology·N Chand, P Eyre
Aug 1, 1976·British Journal of Pharmacology·E Mielens, F J Rosenberg
Aug 1, 1971·Acta Physiologica Scandinavica·A A Mathé, K Strandberg
Jan 27, 1973·British Medical Journal·A A MathéN Svanborg
Sep 1, 1970·Journal of Clinical Pathology·J R O'BrienE Clark
Nov 19, 2013·PloS One·Matthias R MeyerEric R Prossnitz
Jan 1, 1986·Journal of the American Academy of Dermatology·C N EllisJ J Voorhees
May 1, 1983·Journal of the American Academy of Dermatology·C N Ellis, J J Voorhees
Jan 1, 1977·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·B G Simonsson, N Svedmyr
Jun 28, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Derek W Gilroy
Jul 5, 1969·Nature·H O Collier
Apr 27, 1968·Lancet·J R O'Brien
Jul 2, 1971·Nature·H O Collier
Jan 6, 1968·Nature·W J Sweatman, H O Collier
Jan 1, 1973·Current Medical Research and Opinion·P J RooneyW C Dick
Oct 1, 1971·The Journal of Pharmacy and Pharmacology·M J Smith, P D Dawkins
Jun 1, 1969·The Journal of Pharmacy and Pharmacology·G W James
Feb 1, 1971·Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft·D M Hamel, H Oelschläger

Related Concepts

Acetylcholine Sulfate (1: 1)
Anaphylaxis
Angiotensins
Anti-Inflammatory Agents
Bradykinin Hydrochloride
Lobar Bronchus Structure
Cavia porcellus
Ceplene
Lung
Smooth Muscle

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Related Papers

British Journal of Pharmacology and Chemotherapy
H O Collier, P G SHORLEY
British Journal of Pharmacology and Chemotherapy
H O CollierP G SHORLEY
British Journal of Pharmacology and Chemotherapy
K D BHOOLAP G SHORLEY
International Archives of Allergy and Applied Immunology
R D Krell, L W Chakrin
© 2021 Meta ULC. All rights reserved