PMID: 6110561Jan 1, 1980Paper

Bronchodilating drugs and airway reactivity

European Journal of Respiratory Diseases. Supplement
F GuerrinC Voisin

Abstract

Tests with various bronchodilator drugs are utilized in the screening of airway hyperactivity in clinical practice. Bronchodilator tests making use of Salbutamol (Ventoline) as aerosols and by mouth, SCH 1000 as inhalations, Thiazinamium (Multergan) by mouth were performed in 42 patients suffering from bronchial asthma or of chronic obstructive disease, who were investigated by measurement of FEV1, Raw, MEFR. The treatment tests have a variable but significant potency in bronchospastic diseases. Taking into consideration one, two or three signs of bronchodilation, the improvement of FEV1, of MEFR, of airway resistance, the decreasing efficacy of the drug is as follows: SCH 1000 aerosol, Salbutamol aerosol, Salbutamol per os, Thiazinamium per os. The measurement of Raw is the more sensitive exploration to detect the bronchodilator effect of these drugs. The observed bronchodilation may be considered as a criterion of hyperreactivity of the bronchial airways. The differences between the effectiveness of the drugs may allow a better knowledge of the mechanisms of the bronchial airway reactivity and of the treatment of bronchospastic diseases.

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.