PMID: 11905547Mar 22, 2002Paper

Bronchodilating effect of oxitropium bromide in heart disease patients with exacerbations of COPD: double-blind, randomized, controlled study

Respiratory Medicine
S CentanniM Cazzola

Abstract

Anti-cholinergic agents are considered the bronchodilator therapy of first-choice in the treatment of patients with stable chronic obstructive pulmonary disease (COPD) associated with heart disease since they may be as effective or more effective than inhaled beta2-agonists and, moreover, they do not interact with cardiac beta-adrenoceptors. The aim of our study was to evaluate the bronchodilator activity of oxitropium bromide in outpatients suffering from exacerbations of COPD associated with heart diseases (ischaemic heart disease and/or arrhythmias). We recruited 50 consecutive outpatients (33 males and 17 females, mean age 68.6 years, 15 current smokers and 35 ex-smokers). Each patient performed body plethismography in basal condition and 30 min after inhalation of 200 microg metered dose inhaler (MDI) oxitropium bromide administered by a device (Fluspacer). FEV1, FVC, MMEF25-75, sRaw and tRaw were evaluated. Thirty minutes after 200 microg oxitropium bromide administration, we observed a significant improvement in FEV1 11.6% +/- 1 (mean +/- SEM) (P<0.01); FVC, MMEF25-75 sRaw variation was respectively: 9.2% +/- 0.6, 31.4 +/- 2.9, -19.9 +/- 1.1. Placebo did not significantly change pulmonary function. Our data suggest that ...Continue Reading

References

Jun 1, 1987·Chest·M Newhouse, M Dolovich
Feb 1, 1995·Respiratory Medicine·A G StewartP Howard
Jan 1, 1997·Clinical Pharmacokinetics·D J Clark, B J Lipworth
Jun 10, 2000·Chest·R Rodriguez-Roisin

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Citations

Jun 2, 2006·Thorax·R Rodríguez-Roisin
Mar 17, 2007·Respiratory Medicine·Mario CazzolaNicola A Hanania
Jul 22, 2014·The Cochrane Database of Systematic Reviews·Charlotta KarnerPhillippa Poole

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