Bronchodilator effect of deep inspiration and bronchoconstriction-triggered cough.

Cough
Noriyuki OhkuraNobuyuki Katayama

Abstract

Cough in the patients with cough variant asthma is triggered by bronchoconstriction, which responds to bronchodilator therapy. Following airway narrowing induced by inhaled methacholine, deep inspiration (DI) causes dilation of the airways in both asthmatic and non-asthmatic subjects. The aim of the present study was to investigate the relationship between bronchodilator effect of DI and bronchoconstriction-triggered cough. We measured airway responsiveness to methacholine using partial and full flow-volume curves in 28 healthy adults. The expiratory flow at 40% above residual volume from the full forced vital capacity (MEF40) was obtained and the volume was used as the reference volume to determine the isovolume flow from the partial curve (PEF40). Coughs were counted for 32 min during and following the inhalation of methacholine at the provocative concentration which produced a 20% fall or more in FEV1from the post-saline value (PC20-FEV1). The bronchodilator effect of DI on bronchoconstriction induced by methacholine at the PC20-FEV1 concentration was expressed as the ratio of (MEF40-PEF40)/PEF40 (DI index). The number of coughs for 32 min during and following the inhalation of PC20-FEV1 concentration of methacholine was 39....Continue Reading

References

Mar 22, 1979·The New England Journal of Medicine·W M CorraoR S Irwin
Nov 1, 1986·The Journal of Allergy and Clinical Immunology·F E HargreaveE E Daniel
Jan 1, 1994·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M FujimuraT Matsuda
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·T EbiharaH Sasaki
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·C E BrightlingI D Pavord
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·G G KingP D Paré
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·N ScichiloneA Togias
Nov 2, 2002·British Journal of Pharmacology·Yanlin JiaJohn A Hey
Mar 9, 2004·The Journal of Physiology·Brendan J CanningBradley J Undem
Sep 28, 2004·American Journal of Respiratory and Critical Care Medicine·David A GronebergK Fan Chung
Jun 7, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lu WangThomas M Murphy
Jul 9, 2005·Chest·Peter V Dicpinigaitis, Rakesh V Alva
Sep 2, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Heikki O KoskelaHak-Kim Chan
Feb 25, 2006·Journal of Applied Physiology·Roberto TorchioRiccardo Pellegrino
Aug 18, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·UNKNOWN Committee for the Japanese Respiratory Society Guidelines for Management of CoughHarumi Suzaki

❮ Previous
Next ❯

Citations

May 14, 2011·Current Opinion in Pharmacology·Scott E Turcotte, M Diane Lougheed
Jun 24, 2016·Experimental Lung Research·Noriyuki OhkuraMasaki Fujimura
Mar 5, 2016·Journal of Applied Physiology·Nastasia V WasilewskiM Diane Lougheed
Oct 31, 2020·Frontiers in Physiology·Nilita SoodM Diane Lougheed

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Noriyuki OhkuraNobuyuki Katayama
Otolaryngologic Clinics of North America
Dhan Desai, Chris Brightling
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Heikki O KoskelaC Katelaris
American Journal of Respiratory and Critical Care Medicine
Sandra D AndersonA R Clark
© 2022 Meta ULC. All rights reserved