Abstract
In an attempt to find the optimal single therapeutic dose of fenoterol inhalant solution administered by compressor-powered nebulization, bronchodilator and side effects of five different doses of fenoterol (0.5, 1.0, 1.5, 2.0, and 2.5 mg) and of placebo were compared with those of the recommended therapeutic dose delivered from a metered dose canister in 16 patients with reversible airway obstruction. The fenoterol (except for the metered dose) and the placebo were given in a double-blind, cross-over manner. In comparison with placebo, all doses of fenoterol produced a significant increase in average values of FEV1, FEF25-75%, FVC, and SGaw and decrease in FRC for five to eight hours. There was a trend for the bronchodilator action to become greater and more prolonged with increasing doses of fenoterol. Compared with 0.4 mg given from a metered dose canister, 0.5 mg of fenoterol delivered by compressor powered nebulization was equally effective in bronchodilator potency. Dose-by-dose comparison with isoproterenol indicates that fenoterol is a more potent and longer lasting bronchodilator and has no significant effect on heart rate and blood pressures. The most common side effects were shakiness or tremor of hands which appeare...Continue Reading
References
Feb 1, 1977·The Journal of Allergy and Clinical Immunology·W W Simi, W C Miller
Dec 1, 1977·Chest·S N SteenG N Beall
Dec 1, 1977·Chest·B E PennockL N Ayers
Apr 1, 1979·The Journal of Allergy and Clinical Immunology·W C Posey, D G Tinkelman
Oct 1, 1976·Chest·A M GeumeiL R Gast
Sep 1, 1977·Chest·S N SteenG Beall
May 1, 1974·Chest·J BeardshawM Chan-Yeung
Jan 1, 1971·Respiration; International Review of Thoracic Diseases·H M Beumer
Jan 1, 1970·Respiration; International Review of Thoracic Diseases·A Minette
Mar 1, 1956·The Journal of Clinical Investigation·A B DUBOISJ H COMROE
Mar 1, 1956·The Journal of Clinical Investigation·A B DUBOISJ H COMROE
Citations
Mar 1, 1984·The Journal of Allergy and Clinical Immunology·C H FeldmanW J Davis
Mar 1, 1984·The Journal of Pediatrics·J RivlinH Levison
Feb 1, 1986·Australian Paediatric Journal·L I Landau
Dec 7, 2002·Quality & Safety in Health Care·J WrightF Ram
Mar 1, 1986·Chest·S A ConradR B George
Jul 1, 1983·The Journal of Pediatrics·P A ReillyH Levison
Aug 1, 1983·Annals of Emergency Medicine·I G Stiell, R N Rivington
Jul 1, 1985·Chest·D H Bryant
Jan 1, 1987·The American Journal of Medicine·A S RebuckF Vickerson
Jan 1, 1983·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·D GurwitzP A Reilly
Mar 17, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·T KameiJ Takahara
May 23, 2012·Pharmacological Reviews·Mario CazzolaM Gabriella Matera
May 1, 1985·Pharmacotherapy·N Svedmyr
May 1, 1984·Pharmacotherapy·R C Ahrens, G D Smith