PMID: 9648960Jul 2, 1998Paper

Bronchodilator response to salbutamol after spontaneous recovery from nonspecific bronchial provocation tests in asthma

The European Respiratory Journal
R PolosaN Crimi

Abstract

Assessment of airway responsiveness by bronchoprovocation and bronchodilatation tests is important in the diagnostic work-up protocol of bronchial asthma and it would be convenient to undertake both tests on the same occasion. However, it is not known whether this can be done accurately. Therefore, this study evaluated the effect of a prior bronchial provocation test on the bronchodilator response to salbutamol after spontaneous recovery of the forced expiratory volume in one second (FEV1) in a group of asthmatic subjects. On two separate occasions at the same time of day, concentration-response studies with inhaled histamine or methacholine, or a sham challenge with normal saline were carried out in a blinded, randomized manner. Changes in airway calibre were followed as FEV1 and agonist responsiveness expressed as the provocative concentration causing a 20% fall in FEV1 (PC20). After either spontaneous recovery or a fixed-duration wait of 45 min (when appropriate), the subjects received 2x100 microg of salbutamol from a metered dose inhaler with a spacer. The bronchodilator response to salbutamol was expressed as a percentage of initial FEV1 (deltaFEV1% init). Bronchial challenge with both agonists failed to alter significant...Continue Reading

Citations

Jul 11, 2008·Pediatric Pulmonology·Nicole BeydonAndré Denjean
Mar 28, 2006·Respiratory Medicine·Heikki O KoskelaHannu O Tukiainen
Feb 14, 2006·European Journal of Pharmacology·Kenneth J Broadley
Jan 1, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Arvid W A KampsRuurd Jan Roorda
Sep 6, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Kestutis MalakauskasRaimundas Sakalauskas

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