Abstract
This study was undertaken to provide a pharmacological basis for traditional use of Acorus calamus in airways disorders. Isolated guinea-pig trachea and atria were suspended in organ baths bubbled with carbogen and mechanisms were found using different parameters. In isolated guinea-pig tracheal segments, crude extract of Acorus calamus was more effective than carbachol in causing relaxation of high K(+) (80 mM) precontractions, similar to verapamil, suggesting blockade of calcium channels. The n-hexane fraction was equipotent against both precontractions, similar to papaverine, while ethylacetate fraction was more potent against carbachol precontractions but had a negligible dilator effect against K(+), similar to atropine and or rolipram. Pretreatment of tracheal preparations with n-hexane or ethylacetate fractions potentiated isoprenaline-induced inhibitory concentration-response curves, similar to papaverine or rolipram. Pretreatment of tracheal preparations with ethylacetate fraction caused a rightward parallel shift in carbachol response curve at lower concentration (0.003 mg/mL) similar to atropine and a non-parallel shift at higher concentrations (0.01 mg/mL), with reduction of maximum response, similar to rolipram. In ...Continue Reading
References
Jul 1, 1979·Physiological Reviews·T B Bolton
Jan 1, 1992·British Medical Bulletin·P J Barnes
Mar 1, 1967·The Journal of Pharmacy and Pharmacology·M K Menon, P C Dandiya
Jan 28, 1998·Molecular Pharmacology·S IonaM Conti
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·T J Torphy
Nov 27, 1998·Journal of Autonomic Pharmacology·C BoselliE Grana
Jan 5, 2001·British Journal of Pharmacology·D T SchmidtK F Rabe
May 22, 2001·Experimental Biology and Medicine·A A Abdel-Latif
May 30, 2001·Journal of Ethnopharmacology·F G Shoba, M Thomas
Jan 25, 2002·Phytotherapy Research : PTR·Ulyana Muñoz AcuñaEdward J Kennelly
Aug 8, 2002·Phytotherapy Research : PTR·Pradeep K ShuklaR C Srimal
Oct 19, 2002·Fitoterapia·Reshma S Parab, Sushma A Mengi
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Jul 28, 2004·Biochemical Pharmacology·Lérida Guerra de GonzálezMarcelo J Alfonzo
Oct 27, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M H OhJ H Cho
Nov 30, 2005·Fundamental & Clinical Pharmacology·Anwarul Hassan GilaniMunasib Khan
Jan 5, 2006·Respiratory Research·Alasdair J EdgarJulia M Polak
Jan 13, 2006·British Journal of Pharmacology·Victoria Boswell-SmithClive P Page
Feb 21, 2006·European Journal of Pharmacology·Nicholas J Gross
Sep 30, 2006·Phytotherapy Research : PTR·Anwar Ul Hassan GilaniFarzana Shaheen
Dec 11, 2007·Canadian Journal of Physiology and Pharmacology·Anwar H GilaniMuhammad N Ghayur
Feb 7, 2008·Fundamental & Clinical Pharmacology·Anwarul Hassan GilaniSabira Begum
Jun 17, 2009·Journal of Cardiovascular Pharmacology·Abdul Jabbar Shah, Anwarul Hassan Gilani
Sep 16, 2009·Journal of Ethnopharmacology·Arif-ullah Khan, Anwarul Hassan Gilani
Citations
Dec 3, 2011·Journal of Natural Medicines·Munasib KhanAnwarul-Hassan Gilani
Feb 1, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Najeeb-Ur RehmanAnwarul-Hassan Gilani
Nov 10, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sandeep B RajputS Mohan Karuppayil
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Pandy VijayapandiC T Kumarappan
Oct 8, 2011·Clinical and Experimental Hypertension : CHE·Abdul Jabbar Shah, Anwarul Hassan Gilani
Jul 26, 2011·Drug Discovery Today·Frances WatkinsAlberto Sanchez-Medina
Dec 16, 2011·Phytotherapy Research : PTR·Abdul Jabbar Shah, Anwarul Hassan Gilani
Aug 21, 2012·Biomedical Chromatography : BMC·Sreenath NandakumarSunita Shailajan
Apr 14, 2012·Journal of Ethnopharmacology·Munasib KhanAnwarul-Hassan Gilani
Mar 1, 2012·Journal of Ethnopharmacology·Dong-Young KimKwang-Ho Lee
Jan 28, 2015·Pharmaceutical Biology·Munasib KhanAnwarul Hassan Gilani
Jul 12, 2014·Journal of Ethnopharmacology·Nawal ShresthaXian-Chun Zhang
Jun 18, 2014·Journal of Ethnopharmacology·Abdullah I HussainAnwar H Gilani
Oct 4, 2016·Journal of Ethnopharmacology·Musaddique HussainAbdul Majeed
Feb 2, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Amrita Devi KhwairakpamAjaikumar B Kunnumakkara
Mar 22, 2018·Pharmaceutical Biology·Hafiz Misbah-Ud-Din QamarAbdul Jabbar Shah
Mar 13, 2014·Phytotherapy Research : PTR·Munasib KhanAnwarul-Hassan Gilani
Apr 17, 2015·BMC Complementary and Alternative Medicine·Afria ZamanMd Abdul Jalil
Jun 11, 2015·Phytotherapy Research : PTR·Arif-Ullah Khan, Anwarul-Hassan Gilani
Apr 25, 2020·Journal of Clinical Medicine·Vineet SharmaNatália Martins
Jun 27, 2019·Medicines·Mahendra AdhikariPrakash Poudel
Mar 21, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mohd Nazam AnsariFaisal Imam
Apr 23, 2021·Frontiers in Pharmacology·Najeeb Ur RehmanFaisal Imam