Bronchodilatory effect of Acorus calamus (Linn.) is mediated through multiple pathways

Journal of Ethnopharmacology
Abdul J Shah, Anwarul-Hassan Gilani

Abstract

This study was undertaken to provide a pharmacological basis for traditional use of Acorus calamus in airways disorders. Isolated guinea-pig trachea and atria were suspended in organ baths bubbled with carbogen and mechanisms were found using different parameters. In isolated guinea-pig tracheal segments, crude extract of Acorus calamus was more effective than carbachol in causing relaxation of high K(+) (80 mM) precontractions, similar to verapamil, suggesting blockade of calcium channels. The n-hexane fraction was equipotent against both precontractions, similar to papaverine, while ethylacetate fraction was more potent against carbachol precontractions but had a negligible dilator effect against K(+), similar to atropine and or rolipram. Pretreatment of tracheal preparations with n-hexane or ethylacetate fractions potentiated isoprenaline-induced inhibitory concentration-response curves, similar to papaverine or rolipram. Pretreatment of tracheal preparations with ethylacetate fraction caused a rightward parallel shift in carbachol response curve at lower concentration (0.003 mg/mL) similar to atropine and a non-parallel shift at higher concentrations (0.01 mg/mL), with reduction of maximum response, similar to rolipram. In ...Continue Reading

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Citations

Feb 1, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Najeeb-Ur RehmanAnwarul-Hassan Gilani
Nov 10, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sandeep B RajputS Mohan Karuppayil
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Pandy VijayapandiC T Kumarappan
Jul 26, 2011·Drug Discovery Today·Frances WatkinsAlberto Sanchez-Medina
Apr 14, 2012·Journal of Ethnopharmacology·Munasib KhanAnwarul-Hassan Gilani
Jan 28, 2015·Pharmaceutical Biology·Munasib KhanAnwarul Hassan Gilani
Feb 2, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Amrita Devi KhwairakpamAjaikumar B Kunnumakkara
Mar 22, 2018·Pharmaceutical Biology·Hafiz Misbah-Ud-Din QamarAbdul Jabbar Shah
Mar 13, 2014·Phytotherapy Research : PTR·Munasib KhanAnwarul-Hassan Gilani
Jun 11, 2015·Phytotherapy Research : PTR·Arif-Ullah Khan, Anwarul-Hassan Gilani
Mar 21, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mohd Nazam AnsariFaisal Imam

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