PMID: 6975155Nov 15, 1981Paper

Bronchogenic carcinoma: survival after surgical treatment according to stage, histologic type and immunomorphologic changes in regional lymph nodes

Cancer
P TosiA Grossi

Abstract

The survival rates of 90 patients who underwent operation for bronchogenic carcinoma were analyzed statistically according to sex, age, tumor stage and histologic type, types of surgical procedures (lobectomy or pneumonectomy), and to immunomorphologic parameters of immunologic activity in peribronchial and hilar lymph nodes. The Stage I group survived significantly longer than did the Stage II and III groups, the lobectomized patients survived significantly longer than the pneumonectomized patients. The absence or presence of lymph node metastases was one of the major determinants of survival. The mean values (percent of total node cut surface) of lymph node sinus histiocytosis and of paracortical area could be correlated directly to survival in each of the histologic tumor-type groups, while the development of follicular cortex and germinal centers correlated inversely with survival. Increased survival might be associated with changes concomitant with immune reactivity in lymph node T-cell areas and with the sinus histiocytosis pattern, the latter representing probably a tumor--host reaction of the delayed hypersensitivity type. By contrast, increased activity of lymph node B-cell areas tended to correlate with poor prognosis...Continue Reading

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Citations

Nov 7, 2000·Cancer·A Di GiorgioM Scarpini
Dec 1, 1991·Histopathology·M F TungekarD Y Mason
Nov 1, 1984·Pathology, Research and Practice·P TosiR Kraft
Sep 16, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Marc Oliver BodendorfThomas Graeter
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P FoucherL Jeannin
Sep 14, 2019·Journal of Oral and Maxillofacial Pathology : JOMFP·Swetha AcharyaKrithi Nikhil
Jan 19, 2021·Journal of Oral and Maxillofacial Pathology : JOMFP·Hyandavi BallaMadhurya Namana

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