Bronchopulmonary dysplasia - prevalence, severity and predictive factors in a national cohort of extremely premature infants

Acta Paediatrica
T FarstadNorwegian Extreme Prematurity Study Group

Abstract

To study prevalence and predictive factors of bronchopulmonary dysplasia (BPD) in a cohort of preterm infants with a high incidence of prenatal steroid and surfactant treatment. BPD was analysed in a national cohort of infants with gestational age (GA) of 22-27 completed weeks (wks) or birth weight (BW) of 500-999 g. Of 464 infants who were transferred to a NICU, 377 infants with GA ≤ 30 wks and survived beyond 28 days were included in the study. Moderate or severe BPD was strongly related to GA. Of infants with GA 22-25 wks, 67.3% developed BPD compared to 36.6% at GA 26-30 wks. Overall, moderate and severe BPD was significantly more common in boys (63.3%) than in girls (36.6%) (p = 0.0004), but female gender was not a protective factor in infants with GA 22-25 wks. In multivariate analyses, BPD was significantly associated with gender, surfactant treatment and treatment for PDA. BPD remains a severe complication of extreme prematurity in spite of prenatal steroids and surfactant treatment. Whether associations with surfactant and PDA treatment simply reflect severity of early lung disease or have causal relationships should probably be studied in randomized controlled trials.

References

Aug 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·I Y AdamsonG M King
Jul 1, 1995·American Journal of Obstetrics and Gynecology·P A Crowley
Mar 5, 1998·The American Journal of Physiology·N SweezeyH O'Brodovich
Jun 17, 2000·Acta Obstetricia Et Gynecologica Scandinavica·R SkjaervenL S Bakketeig
Mar 10, 2001·The Journal of Pediatrics·L J Van MarterUNKNOWN Neonatology Committee for the Developmental Epidemiology Network
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·S H Abman
Feb 28, 2002·The Journal of Pediatrics·Linda J Van MarterUNKNOWN Developmental Epidemiology Network Investigators
Aug 30, 2002·The New England Journal of Medicine·Alice H JohnsonUNKNOWN United Kingdom Oscillation Study Group
Apr 22, 2004·Clinics in Chest Medicine·Hendrika M BoezenDirkje S Postma
Sep 3, 2004·Pediatrics·Piet VanhaesebrouckUNKNOWN Extremely Preterm Infants in Belgium Study Group
May 4, 2005·Pediatrics·Trond MarkestadUNKNOWN Norwegian Extreme Prematurity Study Group
Sep 1, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·D J Henderson-SmartUNKNOWN Australian and New Zealand Neonatal Network
Jun 19, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michelle A CareyDarryl C Zeldin
Sep 4, 2007·Trends in Endocrinology and Metabolism : TEM·Michelle A CareyDarryl C Zeldin
Nov 9, 2007·The New England Journal of Medicine·Eugenio Baraldi, Marco Filippone
Jan 10, 2009·Archives of Disease in Childhood. Fetal and Neonatal Edition·J V Been, L J I Zimmermann
Jan 28, 2009·Pediatrics·Juliette C MadanUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Jun 6, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN EXPRESS GroupMargareta Wennergren
Nov 13, 2009·Respiratory Medicine·Eva Berggren BroströmMiriam Katz-Salamon

❮ Previous
Next ❯

Citations

Feb 20, 2013·Archives of Gynecology and Obstetrics·Zarqa AliDorthe Lisbeth Jeppesen
May 7, 2013·European Journal of Pediatrics·J K TrittmannM A Klebanoff
May 31, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·P MehtaV Bhandari
Dec 4, 2013·Antioxidants & Redox Signaling·Sara K Berkelhamer, Kathryn N Farrow
Mar 31, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·Y P SaldeñoJ Mirpuri
Dec 15, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·N PlakkalR Sauve
Jan 26, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Edgar Hernandez-AndradeSonia S Hassan
Oct 4, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Paola PapoffCorrado Moretti
Sep 19, 2015·Computers in Biology and Medicine·Marcin Ochab, Wiesław Wajs
Apr 25, 2015·Pediatric Pulmonology·Deborah R LiptzinLynn M Taussig
Aug 5, 2011·Pediatric Pulmonology·Amir Kugelman, Manuel Durand
May 10, 2012·Pediatric Pulmonology·George MandyAlfred Gest
Mar 1, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Deepak Jain, Eduardo Bancalari
Mar 13, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jennifer J P Collins, Bernard Thébaud
Nov 26, 2015·Clinics in Perinatology·Maria PierroBernard Thébaud
Apr 5, 2016·Biology of Sex Differences·Wafae BouhaddiouiYves Tremblay
Jul 29, 2015·Early Human Development·Anne Lee Solevåg, Inger Cathrine Kann
Mar 19, 2013·Free Radical Biology & Medicine·Sara K BerkelhamerPaul T Schumacker
Aug 19, 2015·Frontiers in Medicine·Marius A Möbius, Bernard Thébaud
Apr 2, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Yves Tremblay, Pierre R Provost
Jul 22, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·Q JiangB Sun
Nov 14, 2016·Journal of Pediatric Surgery·Michaela Kollisch-SinguleNader M Habashi
Apr 8, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sheena BouchFoula Sozo
Sep 1, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Muhittin CelikUmut Zubarioglu
Nov 14, 2015·Journal of Korean Medical Science·Heui Seung JoBeyong Il Kim
Jan 4, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Magdalena RutkowskaJanusz Gadzinowski
Feb 23, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Friedrich ReitererBerndt Urlesberger
Aug 10, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Csaba SiffelSujata P Sarda
Aug 19, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Cristian CoarfaKrithika Lingappan
Feb 27, 2020·American Journal of Respiratory and Critical Care Medicine·Gregory SeedorfSteven H Abman
Jun 13, 2019·Scientific Reports·Leanna NguyenClyde J Wright
Jun 14, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Bo SunHongni Yue
Nov 11, 2017·The Cochrane Database of Systematic Reviews·Maria PierroRoger Soll
May 12, 2019·Respiratory Research·Stefanie EndesfelderChristoph Bührer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatrics International : Official Journal of the Japan Pediatric Society
Chang Won ChoiJung Yun Choi
American Journal of Perinatology
Marie-Eve BinetCanadian Neonatal Network™
Current Opinion in Pediatrics
Alan H Jobe
Pediatrics
Barbara J StollEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
© 2021 Meta ULC. All rights reserved