Bronchopulmonary dysplasia early changes leading to long-term consequences

Frontiers in Medicine
Anne Hilgendorff, Michael A O'Reilly

Abstract

Neonatal chronic lung disease, i.e., bronchopulmonary dysplasia, is characterized by impaired pulmonary development resulting from the impact of different risk factors including infections, hyperoxia, and mechanical ventilation on the immature lung. Remodeling of the extracellular matrix, apoptosis as well as altered growth factor signaling characterize the disease. The immediate consequences of these early insults have been studied in different animal models supported by results from in vitro approaches leading to the successful application of some findings to the clinical setting in the past. Nonetheless, existing information about long-term consequences of the identified early and most likely sustained changes to the developing lung is limited. Interesting results point towards a tremendous impact of these early injuries on the pulmonary repair capacity as well as aging related processes in the adult lung.

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Citations

Feb 5, 2016·Pediatric Pulmonology·Yukako MuramatsuKinji Ohno
Jan 19, 2016·Frontiers in Medicine·Ivana Mižíková, Rory E Morty
Jul 14, 2016·Molecular and Cellular Pediatrics·Silke Meiners, Anne Hilgendorff
Jul 13, 2017·Physiological Genomics·Ivana MižíkováRory E Morty
Jan 10, 2017·Disease Models & Mechanisms·Claudio NardielloRory E Morty
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Apr 5, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laurie C EldredgeSteven F Ziegler
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Jun 12, 2020·The American Journal of Pathology·Lakshanie C WickramasingheMargaret L Hibbs
Sep 2, 2021·Clinical & Translational Immunology·Lakshanie C WickramasingheMargaret L Hibbs

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