Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria

Pediatrics International : Official Journal of the Japan Pediatric Society
Friedrich ReitererBerndt Urlesberger

Abstract

Bronchopulmonary dysplasia (BPD) is the most frequent chronic lung disease in infancy and is associated with neonatal comorbidity and impairment in pulmonary and neurodevelopmental (ND) long-term outcome. This was a retrospective, single-center, cohort study to compare a cohort of very preterm infants (gestational age [GA], 24+0 -28+6 weeks) with BPD (n = 44), with a cohort of GA-matched preterm infants without BPD (n = 44) with regard to neonatal morbidity, incidence of lower respiratory tract infection (LRTI), ND outcome and growth to 2 years' corrected age (CA) and preschool age. Bronchopulmonary dysplasia (incidence, 11.3%) was associated with a higher rate of neonatal pneumonia (26% vs 7%, P = 0.001), longer total duration of mechanical ventilation (mean days, 21 vs 13, P < 0.001), and a higher rate of pulmonary hypertension (20.5% vs 0%, P = 0.002) and of severe retinopathy of prematurity (13.6% vs 0%, P = 0.026). Incidence of LRTI was significantly higher in the BPD infants (50% vs 26%, P = 0.025). ND outcome did not differ between the two groups. Growth at neonatal intensive care unit discharge was similar. In the BPD cohort, rate of weight < 10th percentile was higher at 2 years' CA (52% vs 30%, P = 0.041) and rate of ...Continue Reading

References

Jul 31, 1992·Behavioural Brain Research·L S de VriesL M Dubowitz
Apr 1, 1989·Archives of Disease in Childhood·C Amiel-Tison, A Stewart
Feb 1, 1986·Pediatric Clinics of North America·M C Walsh, R M Kliegman
Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Mar 8, 2003·JAMA : the Journal of the American Medical Association·Barbara SchmidtUNKNOWN Trial of Indomethacin Prophylaxis in Preterms (TIPP) Investigators
Sep 19, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Michele C WalshAvroy Fanaroff
Dec 10, 2003·Archives of Ophthalmology·UNKNOWN Early Treatment For Retinopathy Of Prematurity Cooperative Group
Jan 7, 2005·The New England Journal of Medicine·Neil MarlowUNKNOWN EPICure Study Group
Dec 24, 2005·The Pediatric Infectious Disease Journal·Robert L SchelonkaDaniel K Benjamin
Dec 27, 2005·Journal of the American Dietetic Association·Kristy HendricksPaula Ziegler
Jul 25, 2006·Seminars in Perinatology·Peter J Anderson, Lex W Doyle
Apr 14, 2009·Seminars in Fetal & Neonatal Medicine·Jeff M Denney, Jennifer F Culhane
Sep 22, 2009·Seminars in Fetal & Neonatal Medicine·Lex W Doyle, Peter J Anderson
Jul 27, 2010·Acta Paediatrica·T FarstadUNKNOWN Norwegian Extreme Prematurity Study Group
Aug 25, 2010·Neonatology·Ludwig GortnerUNKNOWN members of the MOSAIC Research Group
Aug 26, 2010·Archives of Disease in Childhood. Fetal and Neonatal Edition·Linda J Van MarterUNKNOWN ELGAN Study Investigators
Dec 21, 2010·Current Opinion in Pediatrics·Alan H Jobe
May 7, 2013·European Journal of Pediatrics·J K TrittmannM A Klebanoff
Sep 9, 2015·JAMA : the Journal of the American Medical Association·Barbara J StollUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Nov 20, 2016·Acta Paediatrica·Delaney HinesUNKNOWN International Network for Evaluating Outcomes (iNeo) of Neonates
Jul 1, 2017·European Journal of Pediatrics·Stefano NobileVirgilio P Carnielli
Jul 15, 2017·The Journal of Pediatrics·Alan H Jobe, Robin Steinhorn

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Citations

Jun 13, 2019·Nutrients·Andrea Gila-DiazDavid Ramiro-Cortijo
Jun 25, 2019·BioMed Research International·Ana Maria Solans Pérez de LarrayaJosé Luis García Serrano
Mar 9, 2021·Cell Biochemistry and Biophysics·Ruiwei GaoXiuxiang Liu

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BETA
PMA
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SPSS

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