Bronchopulmonary dysplasia: then and now

Neonatology
Alistair G S Philip

Abstract

When bronchopulmonary dysplasia (BPD) was first described in 1967, the use of assisted ventilation in neonates was in its infancy. High concentrations of oxygen were implicated, and BPD was equated with 'pulmonary oxygen toxicity'. The etiologic role of not only oxygen but also peak inspiratory pressures and the duration of exposure to both was emphasized in the 1970s, but BPD remained a dreaded complication of managing respiratory distress syndrome in the 1980s. It was only after exogenous surfactant became commercially available for endotracheal administration that 'classical' BPD began to disappear and was replaced by the 'new' BPD. 'Classical' BPD was seen in more mature preterm infants (>28 weeks' gestational age) and in its severe form was characterized radiographically by micro- and macrocysts of the lung, lung hyperinflation and flattening of the diaphragms. In contrast, 'new' BPD is seen in less mature infants (<28 weeks' gestational age), has comparatively mild radiographic abnormalities and has been defined as continued oxygen requirement at 36 weeks' postmenstrual age. Pathologically, 'classical' BPD frequently revealed obstructive bronchiolitis and fibrosis of lung parenchyma, whereas 'new' BPD demonstrates minimal...Continue Reading

References

Jun 1, 1978·The Journal of Pediatrics·E R BrownM E Avery
Jan 1, 1991·Archives of Disease in Childhood·D C WilsonJ A Dodge
Jun 8, 1989·The New England Journal of Medicine·J J CummingsS J Gross
Sep 1, 1988·The American Review of Respiratory Disease·L Frank, I R Sosenko
May 1, 1985·Pediatric Pulmonology·O D Saugstad
Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter
Oct 15, 1982·JAMA : the Journal of the American Medical Association·D A ClarkF R Davey
Dec 10, 1999·Pediatric Research·A J Jobe
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Apr 2, 2003·Seminars in Neonatology : SN·Christian P Speer
Apr 2, 2003·Seminars in Neonatology : SN·Jacqueline J Coalson
Nov 3, 2004·Pediatrics·Michele C WalshUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Oct 18, 2005·The Journal of Pediatrics·Kimberly L SpenceAaron Hamvas
May 19, 2006·The New England Journal of Medicine·Barbara SchmidtUNKNOWN Caffeine for Apnea of Prematurity Trial Group
Jul 28, 2006·The New England Journal of Medicine·Roberta A BallardUNKNOWN NO CLD Study Group
Aug 5, 2008·Archives of Disease in Childhood. Fetal and Neonatal Edition·C L BoseM M Laughon
Sep 3, 2008·Pediatrics·Steven H AbmanMarci Sontag
Oct 4, 2008·Neonatology·Christian P Speer, Henry L Halliday
Jun 13, 2009·Pediatrics·UNKNOWN Committee on Injury, Violence, and Poison Prevention
Aug 25, 2009·Seminars in Fetal & Neonatal Medicine·Alistair G S Philip
Aug 27, 2009·Pediatrics·Carl BoseUNKNOWN Extremely Low Gestational Age Newborn Study Investigators
Sep 15, 2009·Seminars in Fetal & Neonatal Medicine·T Allen MerrittBruce R Boynton
May 18, 2010·The New England Journal of Medicine·UNKNOWN SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research NetworkRosemary D Higgins
Oct 1, 2010·Neonatology·Wolfgang Thomas, Christian P Speer
Jun 28, 2011·Neonatology·Christian P Speer
Jun 28, 2011·Neonatology·Rajesh S Alphonse, Bernard Thébaud

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Citations

Jan 4, 2013·British Journal of Anaesthesia·R LauerL Mason
Apr 5, 2013·European Heart Journal·Mony ShuvyChaim Lotan
Jun 6, 2013·Critical Care Nursing Quarterly·E Cuauhtémoc Sánchez
Aug 28, 2012·Neonatology·Kenneth L Sandberg, Ola Hjalmarson
Oct 17, 2013·Paediatric Respiratory Reviews·Wolfgang Thomas, Christian P Speer
Nov 12, 2013·Paediatric Respiratory Reviews·Larry C Lands
Jan 9, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·B M StefanescuT M O'Shea
Aug 29, 2013·American Journal of Respiratory Cell and Molecular Biology·Veniamin RatnerVadim S Ten
Nov 12, 2020·Advanced Science·Mohammadhossein DabaghiP Ravi Selvaganapathy
Jul 2, 2018·Journal of Pediatric Surgery·Joseph T ChurchGeorge B Mychaliska
Oct 8, 2021·Journal of Developmental and Behavioral Pediatrics : JDBP·Ayten BilginSakari Lemola

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