Bronchopulmonary pharmacology of some prostaglandin endoperoxide analogs in the dog

European Journal of Pharmacology
M A Wasserman

Abstract

This investigation examined quantitatively the bronchopulmonary effects of two prostaglandin endoperoxide analogs (cyclic ethers) in the spontaneously breathing, anesthetized dog. Responses to these agents were measured by computer analyses and compared to those produced by prostaglandin F2alpha (PGF2alpha). In a dose range of 0.03-1.0 mug/kg i.v., both cyclic ethers produced dose-related alterations in pulmonary airway resistance dynamic lung compliance, expiratory airflow rate, tidal volume and respiratory frequency. These pulmonary changes were significantly greater than those observed for PGF2alpha (0.3-3.0 mug/kg). The onset of activity was prompt (less than 1 min) and recovery was complete within 5-10 min. Atropine pretreatment greatly reduced the airway resistance effects of all three test agents, thus suggesting some cholinergic component to their potent bronchoconstrictor activities. These cyclic ethers are stable forms of prostaglandin endoperoxides and may represent invaluable pharmacologic tools for the further study of intermediates in prostaglandin synthesis.

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Citations

Feb 15, 1984·Experientia·A Lupulescu
Dec 15, 1977·European Journal of Pharmacology·M A Wasserman, R L Griffin
Feb 1, 1977·Prostaglandins·M A WassermanF G Robinson
Dec 1, 1981·Prostaglandins·E W SpannhakeP J Kadowitz
Jan 1, 1989·Pharmacology & Therapeutics·P J Gardiner
Feb 1, 1985·Prostaglandins, Leukotrienes, and Medicine·M A Wasserman, P E Malo
Jul 1, 1978·Acta Physiologica Scandinavica·P HedqvistM Hamberg
Mar 1, 1977·Circulation Research·P J Kadowitz, A L Hyman
Oct 1, 1981·Australian and New Zealand Journal of Medicine·J P Seale

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