PMID: 22576423May 12, 2012Paper

Bronchoscopy for the diagnosis of pulmonary tuberculosis in patients with negative sputum smear microscopy results

Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Márcia JacomelliViviane Rossi Figueiredo

Abstract

To evaluate the diagnostic accuracy of bronchoscopy in patients with clinical or radiological suspicion of tuberculosis who were unable to produce sputum or with negative sputum smear microscopy results. A prospective cross-sectional study involving 286 patients under clinical or radiological suspicion of having pulmonary tuberculosis and submitted to bronchoscopy-BAL and transbronchial biopsy (TBB). The BAL specimens were submitted to direct testing and culture for AFB and fungi, whereas the TBB specimens were submitted to histopathological examination. Of the 286 patients studied, 225 (79%) were diagnosed on the basis of bronchoscopic findings, as follows: pulmonary tuberculosis, in 127 (44%); nonspecific chronic inflammation, in 51 (18%); pneumocystis, fungal infections, or nocardiosis, in 20 (7%); bronchiolitis obliterans organizing pneumonia, alveolites, or pneumoconiosis, in 14 (5%); lung or metastatic neoplasms, in 7 (2%); and nontuberculous mycobacterium infections, in 6 (2%). For the diagnosis of tuberculosis, BAL showed a sensitivity and a specificity of 60% and 100%, respectively. Adding the TBB findings significantly increased this sensitivity (to 84%), as did adding the post-bronchoscopy sputum smear microscopy res...Continue Reading

References

Nov 1, 1995·American Journal of Respiratory and Critical Care Medicine·C AndersonD Menzies
Mar 26, 2005·The Journal of International Medical Research·L SaglamE Aktas
Apr 20, 2005·Clinics in Chest Medicine·Daniel Brodie, Neil W Schluger

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Citations

Dec 10, 2016·International Journal of Mycobacteriology·Dania Khalid SaeedRumina Hasan
Apr 19, 2015·Journal of Bronchology & Interventional Pulmonology·Shiwan K ShahVincent Valentine
Sep 7, 2016·Nature Medicine·Stephanus T MalherbeStephanie Griffith-Richards
Nov 27, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Hong ZhengYanqin Shen
Mar 30, 2021·Revista iberoamericana de micología·Joycenea da Silva MatsudaFlor Ernestina Martinez-Espinosa

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