Apr 1, 1976

Bronchospasmolytic activity of aqueous aerosols in anesthetized dogs (author's transl)

Arzneimittel-Forschung
R Bauer

Abstract

A modification of the method of Konzett and Rössler is described. This modification allows the administration of atomised drug solutions to anaesthetised dogs. Information is thus obtained on the bronchodilatory activity of a drug and the onset and duration of effect. Two anticholinergics (atropinsulfate and ipratropiumbromide) and three beta-adrenoceptor stimulants (isoprenaline, orciprenaline and salbutamol) were investigated. After local administration as aerosols the anticholinergics proved to be as potent or even more so than the beta-adrenoceptor stimulants.

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Mentioned in this Paper

Anticholinergic mydriatics and cycloplegics
Anticholinergics inhalants for obstructive airway diseases
Broncholytic Effect
Adrenergic beta-Agonists
Metaproterenol
Adrenergic Receptor
Stimulant
Aerosol Dose Form
Isoproterenol
Antispasmodic Effect

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