Brooke-Spiegler Syndrome With Cervical Spine Lesion

Curēus
Valentina VaseninaNoam Stadlan

Abstract

Brooke-Spiegler syndrome (BSS) is a rare hereditary autosomal dominant disorder with variable phenotypic expressivity that results in a variety of benign cutaneous face, scalp, and neck tumors with a histology profile of cylindroma, spiradenoma and trichoepithelioma. Reports of lymph node and distant metastasis are scarce. We present the first case of Brooke-Spiegler syndrome with metastasis to the cervical spine. An 86-year-old female with Brooke-Spiegler syndrome presented to the clinic with a finding of cervical spine lesion involving vertebral body, prevertebral, paraspinal, foraminal, and epidural spaces. The histopathology of the lesion showed benign cylindroma. Considering the location of the lesion and local invasion of neural structures, the malignant transformation of existing tumors could not be excluded. Brooke-Spiegler syndrome rarely presents with malignant transformation and distant metastatic spread. It is important to be aware of these rare cases while monitoring the disease and addressing clinical symptoms. This is to our knowledge the first case of metastatic spread of the cylindroma to the cervical spine resulting in local bone destruction and neural elements compromise. Physicians should be aware of this ra...Continue Reading

References

Feb 1, 1990·Annals of Plastic Surgery·D C HammondW D Simpson
Sep 1, 1993·Cancer·A L GerretsenW A van Vloten
Feb 1, 1996·Annals of Plastic Surgery·L WyldF S Browning
Nov 13, 2001·The British Journal of Dermatology·B K DuraniW Hartschuh
May 25, 2013·International Journal of Surgery Case Reports·Gokhan Giray AkgulMehmet Ali Gulcelik
Mar 15, 2016·Head and Neck Pathology·Dmitry V Kazakov
Mar 24, 2018·The British Journal of Dermatology·S M BrownN Rajan

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